Depression is a prevalent mental illness contributing to significant morbidity. To decrease this substantial public health burden, focus on reducing risk and first incidence of depression during adolescence is a priority. This project, which will innovatively combine risk factor research and evidence-based prevention programs, will advance knowledge on personalized approaches to prevention that may be able to better """"""""bend trajectories"""""""" of depression that surge throughout adolescence. The primary goal of this collaborative R01 study is to examine whether the effects of depression prevention programs can be maximized by matching youth with theoretically-based risk profiles to interventions that fit their needs. This two site study will randomly assign adolescents with high cognitive and/or interpersonal risk to two preventive interventions that are designed to address distinct risk factors for depression: Coping with Stress (CWS), a cognitive behavioral program, and Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), an interpersonal program. We will base these matching profiles on pre-prevention data from a well-characterized sample of youth whom we have been following as part of a collaborative multi-wave naturalistic study to predict developmental trajectories of depression (NIMH 5R01 MH077195/MH077178;Hankin and Young, principal investigators). We will include adolescents, from the original 3rd and 6th grade cohorts, who will be in 7th and 10th grades for this proposed prevention trial. A total of 210 participants across two sites, University of Denver and Rutgers University, will be stratified on cognitive and interpersonal risk and randomized to the two prevention conditions. Independent evaluators will assess participants at baseline, mid-intervention, post-intervention and follow-up (every 6 months up to 36 months post-intervention). The goals of the study are to (1) demonstrate that prevention programs can modify depression trajectories among youth by examining within person changes in trajectories over time (three years before and three years after the prevention programs) and by comparing trajectories of prevention youth with changes in same aged cohorts;(2) evaluate a personalized prevention approach to bending depression trajectories by matching and mismatching youth to either CWS or IPT-AST based on individual risk profiles;(3) examine mechanisms of bending depression trajectories and test whether the prevention programs operate via their hypothesized processes;and (4) explore how genetic susceptibility, emotion regulation, and temperament may affect individual response to IPT-AST and CWS. By implementing evidence-based prevention programs after 3-years of prospective naturalistic data collection, this study will contribute essential data on personalized medicine and altering developmental trajectories of first-onset depression.

Public Health Relevance

The primary goal of this study is to examine whether the effects of depression prevention programs can be maximized by matching youth with different risk profiles to interventions that fit their needs. If personalized prevention approaches are efficacious, they can help reduce rates of depression in adolescence, with its associated impairments and societal costs.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
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Special Emphasis Panel (ZRG1-RPHB-P (03))
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Goldstein, Amy B
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University of Denver
Schools of Arts and Sciences
United States
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Snyder, Hannah R; Young, Jami F; Hankin, Benjamin L (2017) Chronic Stress Exposure and Generation Are Related to the P-Factor and Externalizing Specific Psychopathology in Youth. J Clin Child Adolesc Psychol :1-10
Miller, Adam Bryant; Jenness, Jessica L; Oppenheimer, Caroline W et al. (2017) Childhood Emotional Maltreatment as a Robust Predictor of Suicidal Ideation: A 3-Year Multi-Wave, Prospective Investigation. J Abnorm Child Psychol 45:105-116
Jenness, Jessica L; Young, Jami F; Hankin, Benjamin L (2017) 5-HTTLPR moderates the association between attention away from angry faces and prospective depression among youth. J Psychiatr Res 91:83-89
Oppenheimer, Caroline W; Hankin, Benjamin L; Young, Jami (2017) Effect of Parenting and Peer Stressors on Cognitive Vulnerability and Risk for Depression among Youth. J Abnorm Child Psychol :
Hankin, Benjamin L; Davis, Elysia Poggi; Snyder, Hannah et al. (2017) Temperament factors and dimensional, latent bifactor models of child psychopathology: Transdiagnostic and specific associations in two youth samples. Psychiatry Res 252:139-146
Snyder, Hannah R; Young, Jami F; Hankin, Benjamin L (2017) Strong Homotypic Continuity in Common Psychopathology-, Internalizing-, and Externalizing-Specific Factors Over Time in Adolescents. Clin Psychol Sci 5:98-110
Snyder, Hannah R; Hankin, Benjamin L (2017) All Models Are Wrong, but the p Factor Model Is Useful: Reply to Widiger and Oltmanns (2017) and Bonifay, Lane, and Reise (2017). Clin Psychol Sci 5:187-189
Haraden, Dustin A; Mullin, Benjamin C; Hankin, Benjamin L (2017) The relationship between depression and chronotype: A longitudinal assessment during childhood and adolescence. Depress Anxiety 34:967-976
Snyder, Hannah R; Hankin, Benjamin L (2016) Spiraling out of control: Stress generation and subsequent rumination mediate the link between poorer cognitive control and internalizing psychopathology. Clin Psychol Sci 4:1047-1064
Hankin, Benjamin L; Snyder, Hannah R; Gulley, Lauren D et al. (2016) Understanding comorbidity among internalizing problems: Integrating latent structural models of psychopathology and risk mechanisms. Dev Psychopathol 28:987-1012

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