Anxiety disorders are among the most common psychiatric illnesses in children and adolescents with prevalence rates averaging 5-10%. These disorders are associated with significant short- and long-term impairment in academic, familial, social, and psychological functioning. Although medication and cognitive-behavioral therapies have been found to be effective treatments, efforts to prevent anxiety disorders in youth have been limited. In light of the high prevalence, the associated impairment, and the cost of treating these disorders (estimated at 42 billion dollars a year for adults), preventive measures could have a significant public health impact. Family aggregate studies indicate that children of anxious parents are at an elevated risk for developing anxiety disorders and thus an important target population for prevention. Results from the PI's K23 pilot study found that a brief family-based intervention reduced the incidence of anxiety disorders in this population by 30-50%. The purpose of this R01 application is to evaluate the efficacy of this intervention for reducing anxiety symptoms and preventing the onset of anxiety disorders in the offspring of anxious parents. In addition, this study will examine theoretically-based mediators of intervention effects. The intervention will be evaluated using a 2 (intervention condition: prevention versus an information- monitoring control) x 4 (assessment period: pre-, post-intervention, 6-, and 12-month follow-up) experimental design. This study uses rigorous scientific methods including a randomized controlled design, multiple informants and measures to assess key constructs, independent evaluators (IEs) to assess outcome and mediator variables, and intensive training for therapists and IEs to assure a high quality of study implementation. This study will be the first aimed at preventing anxiety disorders in the offspring of anxious parents. This application responds to recommendations made by the National Advisory Mental Health Work Group on Mental Disorders Prevention Research (2001) and earlier recommendations from both the Institute of Medicine's Committee on Prevention of Mental Disorders and the NIMH's Prevention Steering Committee (Mrazek &Haggerty, 1994) to develop and evaluate preventive interventions for youth. Anxiety disorders in children and adolescents are common and debilitating illnesses. While cognitive-behavioral treatment is effective, prevention efforts would have a significant public health impact by reducing the need for treatment and altering the life trajectories of at risk children. Offspring of anxious adults are at a significant risk for developing these disorders and an important target for prevention efforts. The purpose of this R01 application is to evaluate whether a short-term psychosocial intervention, developed by the PI in a pilot study, can prevent the onset of anxiety disorders in the offspring of anxious parents.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
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Study Section
Special Emphasis Panel (ZMH1-ERB-N (07))
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Avenevoli, Shelli A
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Johns Hopkins University
Schools of Medicine
United States
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Platt, Rheanna; Williams, Sarah R; Ginsburg, Golda S (2016) Stressful Life Events and Child Anxiety: Examining Parent and Child Mediators. Child Psychiatry Hum Dev 47:23-34
Pella, Jeffrey E; Drake, Kelly L; Tein, Jenn-Yun et al. (2016) Child Anxiety Prevention Study: Impact on Functional Outcomes. Child Psychiatry Hum Dev :
Ginsburg, Golda S; Drake, Kelly L; Tein, Jenn-Yun et al. (2015) Preventing Onset of Anxiety Disorders in Offspring of Anxious Parents: A Randomized Controlled Trial of a Family-Based Intervention. Am J Psychiatry 172:1207-14
Keeton, Courtney P; Teetsel, Rebekah N; Dull, Nicole Marie S et al. (2015) Parent Psychopathology and Children's Psychological Health: Moderation by Sibling Relationship Dimensions. J Abnorm Child Psychol 43:1333-42
Teetsel, Rebekah N; Ginsburg, Golda S; Drake, Kelly L (2014) Anxiety-promoting parenting behaviors: a comparison of anxious mothers and fathers. Child Psychiatry Hum Dev 45:133-42
Crosby Budinger, Meghan; Drazdowski, Tess K; Ginsburg, Golda S (2013) Anxiety-promoting parenting behaviors: a comparison of anxious parents with and without social anxiety disorder. Child Psychiatry Hum Dev 44:412-8
Affrunti, Nicholas W; Ginsburg, Golda S (2012) Maternal overcontrol and child anxiety: the mediating role of perceived competence. Child Psychiatry Hum Dev 43:102-12
Affrunti, Nicholas W; Ginsburg, Golda S (2012) Exploring Parental Predictors of Child Anxiety: The Mediating Role of Child Interpretation Bias. Child Youth Care Forum 41:517-527
Festa, Candice C; Ginsburg, Golda S (2011) Parental and peer predictors of social anxiety in youth. Child Psychiatry Hum Dev 42:291-306
Drake, Kelly L; Ginsburg, Golda S (2011) Parenting Practices of Anxious and Non-Anxious Mothers: A Multi-method Multi-informant Approach. Child Fam Behav Ther 33:299-321

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