Adolescence is a developmental period involving both heightened reward sensitivity and risk for bipolar spectrum disorders (BSDs). Despite their prevalence and public health significance, major unanswered questions exist regarding the mechanisms involved in vulnerability to BSDs. Recent exciting research provides strong and consistent support for a Behavioral Approach System (BAS)/reward hypersensitivity theory of BSDs that shows great promise for elucidating and integrating the neurobiological, behavioral, and environmental mechanisms underlying risk along the bipolar spectrum. In addition, research on social and circadian rhythm models of BSDs is also very promising, but has proceeded independently of research on reward sensitivity. Yet, our recent work demonstrates influences of reward sensitivity on social rhythm disruption and mood symptoms, leading us to a novel integration of reward sensitivity and social rhythm dysregulation in this application. Thus, the overarching goal of this proposal is to use an innovative biobehavioral high-risk design in adolescents to examine two interrelated processes that may help explain the association between reward hypersensitivity and BSDs: 1) heightened activation of a """"""""reward-related"""""""" neural network involving the ventral striatum and orbitofrontal cortex;and 2) influences of reward sensitivity/activation on social rhythm disruption. We will continue to follow High and Moderate BAS/reward sensitive adolescents as they further age into the period of risk for BSDs with self-report and behavioral measures of reward sensitivity/processing, BAS-relevant cognitive styles, social rhythms, BAS-relevant and social rhythm disruption life events, and mood symptoms/ diagnoses. We also will conduct a new and novel neuroimaging study. We will compare High BAS adolescents who have developed BSD (HBAS+BSD), High BAS adolescents who have not yet exhibited, but are at risk for, BSD (HBAS), and Moderate BAS adolescents without BSD (MBAS) on reward-related brain activity and connectivity in response to the anticipation and receipt of monetary rewards in an fMRI study. In addition, we will examine the influence of reward sensitivity/activation and social rhythm dysregulation on mood symptoms in these same three groups of adolescents. This research program is the first to examine neural trait markers and social rhythm dysregulation in adolescents at risk for BSDs based on a hypothesized psychobiological vulnerability. It will provide tools for the early identification of adolescents at risk for first onset and a worse course of BSD, inform our understanding of specific etiological pathways and biobehavioral mechanisms involved in illness onset, recurrence, and progression, and contribute to the development of early psychosocial, pharmacological, and neuroprotective strategies targeted at ameliorating reward processing abnormalities.

Public Health Relevance

Knowledge of the mechanisms that lead to vulnerability to bipolar spectrum disorders (BSDs) is important to the development of interventions to treat or prevent these impairing conditions. To the extent that hyper- sensitivity to rewards and social rhythm dysregulation combine to influence risk for BSDs, successful interventions must target vulnerable individuals'reward processing and regularize their social rhythms. The proposed studies will use biobehavioral and fMRI methods to yield insights into the effects of hypersensitive reward processing and social rhythm disruption on risk for BSDs, to provide tools for early identification of adolescents at risk for BSDs and inform the development of more effective, targeted intervention strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH077908-07
Application #
8696878
Study Section
Adult Psychopathology and Disorders of Aging Study Section (APDA)
Program Officer
Avenevoli, Shelli A
Project Start
2006-08-01
Project End
2018-06-30
Budget Start
2014-07-31
Budget End
2015-06-30
Support Year
7
Fiscal Year
2014
Total Cost
$685,068
Indirect Cost
$228,769
Name
Temple University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
057123192
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Pornpattananangkul, Narun; Nusslock, Robin (2016) Willing to wait: Elevated reward-processing EEG activity associated with a greater preference for larger-but-delayed rewards. Neuropsychologia 91:141-162
Ammerman, Brooke A; Burke, Taylor A; Alloy, Lauren B et al. (2016) Subjective pain during NSSI as an active agent in suicide risk. Psychiatry Res 236:80-5
Boland, Elaine M; Stange, Jonathan P; Labelle, Denise R et al. (2016) Affective Disruption from Social Rhythm and Behavioral Approach System (BAS) Sensitivities: A Test of the Integration of the Social Zeitgeber and BAS Theories of Bipolar Disorder. Clin Psychol Sci 4:418-432
Gibson, Lauren E; Alloy, Lauren B; Ellman, Lauren M (2016) Trauma and the psychosis spectrum: A review of symptom specificity and explanatory mechanisms. Clin Psychol Rev 49:92-105
Ng, Tommy H; Stange, Jonathan P; Black, Chelsea L et al. (2016) Impulsivity predicts the onset of DSM-IV-TR or RDC hypomanic and manic episodes in adolescents and young adults with high or moderate reward sensitivity. J Affect Disord 198:88-95
Alloy, Lauren B; Olino, Thomas; Freed, Rachel D et al. (2016) Role of Reward Sensitivity and Processing in Major Depressive and Bipolar Spectrum Disorders. Behav Ther 47:600-621
Burke, Taylor A; Hamilton, Jessica L; Cohen, Jonah N et al. (2016) Identifying a physical indicator of suicide risk: Non-suicidal self-injury scars predict suicidal ideation and suicide attempts. Compr Psychiatry 65:79-87
Hamilton, Jessica L; Kleiman, Evan M; Rubenstein, Liza M et al. (2016) Deficits in Emotional Clarity and Vulnerability to Peer Victimization and Internalizing Symptoms Among Early Adolescents. J Youth Adolesc 45:183-94
Pornpattananangkul, Narun; Hu, Xiaoqing; Nusslock, Robin (2015) Threat/reward-sensitivity and hypomanic-personality modulate cognitive-control and attentional neural processes to emotional stimuli. Soc Cogn Affect Neurosci 10:1525-36
Burke, Taylor A; Stange, Jonathan P; Hamilton, Jessica L et al. (2015) Cognitive and Emotion-Regulatory Mediators of the Relationship Between Behavioral Approach System Sensitivity and Nonsuicidal Self-Injury Frequency. Suicide Life Threat Behav 45:495-504

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