Numerous psychiatric disorders can plague the development of children. Each of these disorders manifests as a distinct pattern of clinical, behavioral, etiological, neuroanatomic, and neurofunctional characteristics that challenge the management of the individual patient, as well as the development of successful intervention and prevention strategies. In the area of neuroimaging, a substantial number of studies have been performed;while each study produces a wealth a clinical and imaging data, most of this information remains an untapped resource due to ineffective use of the principles of data sharing and integration. This proposal seeks to develop a set of cohesive neuroinformatics resources to foster integrated research efforts in the study of children with mental illness. This effort is designed to capitalize on the extensive database of over 250 high-resolution volumetric MRI data and associated analyses that has been generated by the Child and Adolescent Neuropsychiatric Research Program (CANRP) at Cambridge Health Alliance (CHA), in conjunction with the Center for Morphometric Analysis (CMA) at the MGH, and the integrated web resources of the Internet Brain Segmentation Repository (IBSR) and the Internet Brain Volume Database (IBVD). As such, this will constitute the first known """"""""Knowledge Environment"""""""" for the integrated understanding of the quantitative neuroanatomy in this population of children with psychiatric disorders.

Public Health Relevance

Numerous psychiatric disorders can plague the development of children. Each of these disorders manifests as a distinct pattern of clinical, behavioral, and neuroanatomic traits that challenge the management of the individual patient, as well as the development of successful intervention and prevention strategies. This project will develop a set of cohesive neuroinformatics resources that will help to integrate research efforts to advance the diagnosis and treatment of these disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH083320-03
Application #
8080393
Study Section
Neurotechnology Study Section (NT)
Program Officer
Friedman-Hill, Stacia
Project Start
2009-08-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
3
Fiscal Year
2011
Total Cost
$366,424
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Psychiatry
Type
Schools of Medicine
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
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