Progress in pharmacologic and behavioral treatments for schizophrenia depends in part on developing new and valid approaches for assessing cognitive dysfunction. Specialized behavioral measures are required to characterize the integrity of specific cognitive mechanisms in persons with schizophrenia. The overall aims of this project are to develop efficient batteries for assessment of early auditory and visual research deficits in schizophrenia. In the auditory system, patients show reliable deficits on behavioral measures such as tone matching (TMT) and distorted tunes (DTT) task identification, which correlate with disturbance in generation of ERP components such as mismatch negativity (MMN) and auditory N1. Basic deficits in tone matching, moreover, upward generalize to produce deficits in such """"""""real world"""""""" processes as auditory emotion identification, phonological reading analysis and phonemic identification. In the visual system, patients show reliable deficits in ability to detect low contrast, low spatial frequency stimuli, which correlate with disturbances in generation of ERP components such as steady-state VEP, and transient visual P1, particularly to low spatial frequency (magnocellular selective) stimuli. Deficits in early visual processing contribute to impairment in higher order processes such as perceptual closure and reading. For both auditory and visual systems, patterns of dysfunction correspond to predictions of NMDA models of schizophrenia. Narrative Schizophrenia is a major neuropsychiatric disorder that affects approximately 1% of the population worldwide. Cognitive dysfunction represent a core component of schizophrenia and a major cause of chronic disability. In addition to other cognitive deficits, individuals with schizophrenia have difficulty in the processing of sensory information such as matching tones following brief delay or recognizing certain types of visual stimuli. These low-level deficits interfere with patient's ability to perform more complex tasks, such as identifying emotions when other's speak to them, or recognizing pictures when they are only able to see fragments of the overall image. These abnormalities can be measured both behaviorally and by measuring """"""""brain waves"""""""" while patients are listening to tones or looking at pictures. This project will develop standardized approaches to analyze sensory deficits in schizophrenia. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH084848-01
Application #
7563122
Study Section
Special Emphasis Panel (ZMH1-ERB-Z (04))
Program Officer
Kozak, Michael J
Project Start
2008-09-26
Project End
2011-05-31
Budget Start
2008-09-26
Budget End
2009-05-31
Support Year
1
Fiscal Year
2008
Total Cost
$515,505
Indirect Cost
Name
New York University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
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Abeles, Ilana Y; Gomez-Ramirez, Manuel (2014) Impairments in background and event-related alpha-band oscillatory activity in patients with schizophrenia. PLoS One 9:e91720
Kantrowitz, J T; Hoptman, M J; Leitman, D I et al. (2014) The 5% difference: early sensory processing predicts sarcasm perception in schizophrenia and schizo-affective disorder. Psychol Med 44:25-36
Kantrowitz, Joshua T; Leitman, David I; Lehrfeld, Jonathan M et al. (2013) Reduction in tonal discriminations predicts receptive emotion processing deficits in schizophrenia and schizoaffective disorder. Schizophr Bull 39:86-93
Calderone, Daniel J; Martinez, Antigona; Zemon, Vance et al. (2013) Comparison of psychophysical, electrophysiological, and fMRI assessment of visual contrast responses in patients with schizophrenia. Neuroimage 67:153-62
Calderone, Daniel J; Hoptman, Matthew J; Martínez, Antígona et al. (2013) Contributions of low and high spatial frequency processing to impaired object recognition circuitry in schizophrenia. Cereb Cortex 23:1849-58
Gold, Rinat; Butler, Pamela; Revheim, Nadine et al. (2012) Auditory emotion recognition impairments in schizophrenia: relationship to acoustic features and cognition. Am J Psychiatry 169:424-32
Butler, Pamela D; Chen, Yue; Ford, Judith M et al. (2012) Perceptual measurement in schizophrenia: promising electrophysiology and neuroimaging paradigms from CNTRICS. Schizophr Bull 38:81-91

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