Individuals with serious mental illness (SMI) die earlier than individuals in the general population, losing on average, 9-32 years of life. Much of the premature mortality among the SMI is due to medical comorbidities such as diabetes (DM) which has achieved epidemic proportions. While co-occurring SMI and DM (SMI-DM) are major public health problems, there are few effective treatment models for SMI patients with co-occurring illnesses that are widely utilizable in clinical settings. Practical treatment approaches are needed for patients with SMI-DM, because models of care that only focus on one condition without the other are likely to fail among individuals challenged with both SMI and DM. Effective models of care for mentally ill individuals with DM also should be generalizable and need to be readily adaptable to related medical conditions such as metabolic syndrome and obesity. The primary care setting offers a unique venue for teaching skills necessary for mental illness and medical self-management. Positive pilot research findings by these investigators have informed this project, which maps precisely onto NIMH Strategic Objective 3: """"""""Develop New and Better Interventions for Mental Disorders that Incorporate the Diverse Needs and Circumstances of People with Mental Illness."""""""" This project is a randomized, controlled trial (RCT) of a psychosocial intervention, Targeted Training in Illness Management (TTIM), intended to improve mental health symptoms, functioning, and quality of life as well as diabetes health outcomes in 100 individuals with SMI-DM vs. 100 individuals with SMI-DM receiving treatment as usual (TAU). TTIM is designed to overcome barriers to the complex problem of co- management of SMI and medical disorders and will focus on enhancing active participation of the SMI patients in the care of their illnesses. Nurse Educators will work together with Peer Educators to lead intervention sessions that facilitate communication, boost self-efficacy, and model behavioral changes. Secondary outcomes include adherence to medications for SMI and DM and engagement in healthy behaviors. Key factors previously identified as facilitators or barriers to optimal self-management of SMI and of DM will be targeted by the intervention and measured during the study. An important enhancement to the RCT is a qualitative assessment of facilitators and barriers for concurrent SMI-DM management from the perspective of individuals with SMI-DM. Interventions like TTIM that require relatively limited resources and that can be introduced into existing care systems with existing staff have the potential for wide-spread uptake in real-world settings and hold promise for improving care for high-risk, vulnerable individuals with SMI.

Public Health Relevance

This project tests a model for improving illness self-management among persons who have both serious mental illness and diabetes and will be performed within a primary care setting at a safety net hospital system. The information gained from the randomized trial will be supplemented with reports from participants about their experiences of trying to improve illness self-management. Improvements in self-management should result in a reduction of psychiatric symptoms and improvements in functioning and physical health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH085665-03
Application #
8460083
Study Section
Mental Health Services in Non-Specialty Settings (SRNS)
Program Officer
Azrin, Susan
Project Start
2011-07-01
Project End
2016-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
3
Fiscal Year
2013
Total Cost
$569,857
Indirect Cost
$205,263
Name
Case Western Reserve University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Sajatovic, Martha; Howland, Molly; Gunzler, Douglas et al. (2018) Race analysis in an African American sample with serious mental illness and comorbid diabetes. Psychiatr Rehabil J 41:246-252
Blixen, Carol; Kanuch, Stephanie W; Perzynski, Adam T et al. (2018) What Works in a Nurse Led Self-Management Program for Patients with Serious Mental Illness (SMI) and Diabetes (DM). Arch Psychiatr Nurs 32:127-132
Aftab, Awais; Bhat, Chetan; Gunzler, Douglas et al. (2018) Associations among comorbid anxiety, psychiatric symptomatology, and diabetic control in a population with serious mental illness and diabetes: Findings from an interventional randomized controlled trial. Int J Psychiatry Med 53:126-140
Sajatovic, Martha; Gunzler, Douglas D; Kanuch, Stephanie W et al. (2017) A 60-Week Prospective RCT of a Self-Management Intervention for Individuals With Serious Mental Illness and Diabetes Mellitus. Psychiatr Serv 68:883-890
Gunzler, Douglas D; Morris, Nathan; Dalton, Jarrod E et al. (2017) Clinic Appointment Attendance in Adults with Serious Mental Illness and Diabetes. Am J Health Behav 41:810-821
Gunzler, Douglas; Sajatovic, Martha; McCormick, Richard et al. (2017) Psychosocial Features of Clinically Relevant Patient Subgroups With Serious Mental Illness and Comorbid Diabetes. Psychiatr Serv 68:96-99
Blixen, Carol E; Kanuch, Stephanie; Perzynski, Adam T et al. (2016) Barriers to Self-management of Serious Mental Illness and Diabetes. Am J Health Behav 40:194-204
Sajatovic, Martha; Gunzler, Douglas; Einstadter, Douglas et al. (2016) A Preliminary Analysis of Individuals With Serious Mental Illness and Comorbid Diabetes. Arch Psychiatr Nurs 30:226-9
Kanuch, Stephanie W; Cassidy, Kristin A; Dawson, Neal V et al. (2016) Recruiting and Retaining Individuals with Serious Mental Illness and Diabetes in Clinical Research: Lessons Learned from a Randomized, Controlled Trial. J Health Dispar Res Pract 9:115-126
Lawless, Mary Ellen; Kanuch, Stephanie W; Martin, Siobhan et al. (2016) A Nursing Approach to Self-Management Education for Individuals With Mental Illness and Diabetes. Diabetes Spectr 29:24-31

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