This research focuses on the co-development and co-regulation of the sleep and emotion processes during early childhood (ages 2-5 years).
The specific aims of this research are (1) to examine the early developmental progression of sleep homeostasis (i.e., accumulation and dissipation);(2) to examine early developmental changes in the circadian process (i.e., phase, amplitude, phase angle of entrainment);and (3) to determine the impact of acute sleep restriction on physiological and behavioral measures of emotion regulation. Given the prevalence of early emotional/behavioral problems (7%-24%) and their stability, identifying factors that may alter pathways to mental illness is critical. Sleep-wake regulation is one such factor. Healthy, normally developing young children (n=40;ages 2-5 years) will participate in four annual 30-day in-home assessments of sleep homeostasis, circadian rhythms, and emotion regulation.
Aim 1 addresses developmental changes in the accumulation (build up) and dissipation (decay) of sleep homeostasis. Children are studied while following a strict sleep wake schedule. On five non-consecutive days, the timing of polysomnographic sleep recordings varies as a function of prior wakefulness. EEG spectral power in the slow- wave activity range (.75Hz-4.5Hz) is computed in NREM sleep after 4hrs, 7hrs, 10hrs, 13hrs, and 16hrs of extended wakefulness. Accumulation parameters (time constant, upper asymptote) are estimated by SWA in the first NREM sleep episode of each recording. Dissipation is measured as the time course of SWA during NREM sleep episodes in all-night recordings (13hrs and 16hrs extended wakefulness).
Aim 2 addresses developmental changes in circadian measures, including circadian phase [salivary dim-light melatonin onset (DLMO)], urinary melatonin amplitude, and phase angle of entrainment (DLMO-to-bedtime and DLMO-to-wake time intervals).
The third aim addresses the effects of sleep restriction on emotion regulation in structured and unstructured home-based contexts. It is hypothesized that sleep restriction will (a) increases negative responsivity;(b) decrease positive responsivity;(c) decrease attention, inhibitory control, and use of adaptive regulation strategies;and (d) heighten physiological responses (respiratory sinus arrhythmia, cortisol reactivity) to emotionally eliciting stimuli/situations

Public Health Relevance

Emotional/behavioral problems are prevalent in young children (7%-24%) and commonly persist into adolescence and adulthood. Identifying mechanisms that contribute to the development of mental illness and understanding intra- and inter-individual differences in brain-behavior interactions is critical. This longitudinal research focuses on sleep bioregulation as a factor that may alter pathways to mental illness by studying the co-development and co-regulation of the sleep and emotion systems in early childhood. An integrative understanding of these systems may uncover points of entry for prevention and treatment of mental illness.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH086566-04
Application #
8217187
Study Section
Biobehavioral Mechanisms of Emotion, Stress and Health Study Section (MESH)
Program Officer
Vicentic, Aleksandra
Project Start
2010-04-26
Project End
2015-01-31
Budget Start
2012-02-01
Budget End
2013-01-31
Support Year
4
Fiscal Year
2012
Total Cost
$515,315
Indirect Cost
$150,015
Name
University of Colorado at Boulder
Department
Physiology
Type
Schools of Arts and Sciences
DUNS #
007431505
City
Boulder
State
CO
Country
United States
Zip Code
80309
McClain, Ian J; Lustenberger, Caroline; Achermann, Peter et al. (2016) Developmental Changes in Sleep Spindle Characteristics and Sigma Power across Early Childhood. Neural Plast 2016:3670951
Mullins, Elsa N; Miller, Alison L; Cherian, Sherin S et al. (2016) Acute sleep restriction increases dietary intake in preschool-age children. J Sleep Res :
Kurth, Salome; Lassonde, Jonathan M; Pierpoint, Lauren A et al. (2016) Development of nap neurophysiology: preliminary insights into sleep regulation in early childhood. J Sleep Res 25:646-654
Kurth, Salome; Dean 3rd, Douglas C; Achermann, Peter et al. (2016) Increased Sleep Depth in Developing Neural Networks: New Insights from Sleep Restriction in Children. Front Hum Neurosci 10:456
Schumacher, Allyson M; Miller, Alison L; Watamura, Sarah E et al. (2016) Sleep Moderates the Association Between Response Inhibition and Self-Regulation in Early Childhood. J Clin Child Adolesc Psychol :1-14
de Jong, Desiree M; Cremone, Amanda; Kurdziel, Laura B F et al. (2016) Maternal Depressive Symptoms and Household Income in Relation to Sleep in Early Childhood. J Pediatr Psychol 41:961-70
Lassonde, Jonathan M; Rusterholz, Thomas; Kurth, Salome et al. (2016) Sleep Physiology in Toddlers: Effects of Missing a Nap on Subsequent Night Sleep. Neurobiol Sleep Circadian Rhythms 1:19-26
Tribble, Rebekah C; Dmitrieva, Julia; Watamura, Sarah E et al. (2015) The cortisol awakening response (CAR) in toddlers: Nap-dependent effects on the diurnal secretory pattern. Psychoneuroendocrinology 60:46-56
Kurth, Salome; Olini, Nadja; Huber, Reto et al. (2015) Sleep and Early Cortical Development. Curr Sleep Med Rep 1:64-73
Miller, Alison L; Lumeng, Julie C; LeBourgeois, Monique K (2015) Sleep patterns and obesity in childhood. Curr Opin Endocrinol Diabetes Obes 22:41-7

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