Major depressive disorder (MDD) is a common illness that often has chronic or recurring course. Prevention is believed to be the key to reducing the burden of this disorder. However, an effective prevention program requires thorough knowledge of predisposing factors and mechanisms by which they convey risk. Personality characteristics are powerful predictors of MDD onset, but it is not yet clear which traits are the best markers of vulnerability. Also, the mechanisms underlying these links are not well understood. This project aims to identify main personality risk factors for depression onset and elucidate relevant etiologic processes, including interactions with life stress as well as neural and endocrinal mechanisms. Another objective is to learn how much concomitant depression distorts scores on personality measures, thus informing basic personality research and clinical assessment. We propose to recruit 575 14- and 15-year-old females (demographic stratum at highest risk for incident depression) who have never experienced a major depressive episode. Participants will be assessed in person three times: at baseline, month 18, and month 36. They will complete a thorough diagnostic interview, a battery of personality scales, as well as measures of negative life events, daily functioning, cortisol levels, and brain activity. They also will participate in brief phone interviews between assessments to minimize biases in recall of depressive episodes and stressful life events. Family psychiatric history and informant-ratings of personality will be obtained from a parent. We will use Structural Equation Modeling (SEM) to estimate trait scores with high precision, and growth modeling to remove distortions in these ratings induced by concomitant depression. We expect these analytic strategies to substantially enhance power of our analyses and will develop formulas for correcting personality scores in future studies. Next, we will examine the dynamic interplay between personality and environment in development of vulnerability to MDD. We also will test two promising biomarkers of pathological developmental trajectories. Furthermore, we will develop a personality screen to identify adolescents at risk well before they experienced depression. This multidisciplinary project will form the basis for a program of research that ultimately seeks to design and target new preventive interventions for adolescent depression.

Public Health Relevance

The goal of this project is to identify adolescent women at risk for major depression and find new opportunities to prevent development of depression. To achieve this aim we will follow a sample of 575 healthy 14- and 15-year-old girls and will try to predict who becomes depressed over the next 3 years. Our findings will help researchers to develop and target new preventive measures.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
4R01MH093479-05
Application #
8997526
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Murphy, Eric Rousseau
Project Start
2012-02-17
Project End
2017-01-31
Budget Start
2016-02-01
Budget End
2017-01-31
Support Year
5
Fiscal Year
2016
Total Cost
Indirect Cost
Name
State University New York Stony Brook
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
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Kopala-Sibley, Daniel C; Klein, Daniel N; Perlman, Greg et al. (2017) Self-criticism and dependency in female adolescents: Prediction of first onsets and disentangling the relationships between personality, stressful life events, and internalizing psychopathology. J Abnorm Psychol 126:1029-1043
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Goldstein, Brandon L; Perlman, Greg; Kotov, Roman et al. (2017) Etiologic specificity of waking Cortisol: Links with maternal history of depression and anxiety in adolescent girls. J Affect Disord 208:103-109
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Weinberg, Anna; Meyer, Alexandria; Hale-Rude, Emily et al. (2016) Error-related negativity (ERN) and sustained threat: Conceptual framework and empirical evaluation in an adolescent sample. Psychophysiology 53:372-85
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