Posttraumatic stress disorder (PTSD) is common and debilitating. Because the development of PTSD is conditional on trauma exposure, PTSD may be the most preventable of mental disorders. We have the unique opportunity to reduce the population burden of PTSD by both by preventing trauma exposure and by delivering timely interventions to those most at risk in the aftermath of exposure. However, limitations of extant epidemiologic studies have hindered progress in our understanding of when, where and how to intervene - with regard to PTSD. This application seeks support for a program of research that examines the prevalence of and risk and protective factors for the three stages of PTSD: trauma exposure, onset, and chronic course. This project uses data from the coordinated national population surveys participating in the World Mental Health (WMH) Survey Initiative. The unprecedented size, representativeness, and richness of the WMH database provide a unique opportunity to develop a comprehensive model of PTSD etiology. We will validate this model using longitudinal data from the National Comorbidity Survey panel sample (NCSII). Analyses will address the following specific aims: 1) Determine the cross- national public health burden of PTSD in relation to specific types of traumatic event;2) Develop a model of the etiology of trauma exposure and PTSD;3) Identify factors associated with PTSD chronicity, severity, and the development of subsequent comorbid disorders. Through accomplishment these aims, we will identify malleable and robust risk factors for the different phases of PTSD and provide novel information on how cultural diversity influences each of these phases. The results are expected to generate significant progress in scientific, clinical, and policy efforts aimed at the prediction and prevention of PTSD.

Public Health Relevance

The aims of this project are to analyze data from the WHO World Mental Health Surveys to develop a wide-ranging assessment of the cross-national public health burden of posttraumatic stress disorder and a comprehensive model of its etiology. The results of this study inform research, policy, and practice by identifying malleable and robust risk factors for the different phases of PTSD: trauma exposure, disease onset, and course and providing novel information on how cultural diversity influences each of these phases.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
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Study Section
Behavioral Genetics and Epidemiology Study Section (BGES)
Program Officer
Tuma, Farris K
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Columbia University (N.Y.)
Public Health & Prev Medicine
Schools of Public Health
New York
United States
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McLaughlin, Katie A; Koenen, Karestan C; Friedman, Matthew J et al. (2015) Subthreshold posttraumatic stress disorder in the world health organization world mental health surveys. Biol Psychiatry 77:375-84
Olaya, B; Alonso, J; Atwoli, L et al. (2015) Association between traumatic events and post-traumatic stress disorder: results from the ESEMeD-Spain study. Epidemiol Psychiatr Sci 24:172-83
Borges, Guilherme; Benjet, Corina; Petukhova, Maria et al. (2014) Posttraumatic stress disorder in a nationally representative mexican community sample. J Trauma Stress 27:323-30
Miret, Marta; Caballero, Francisco Félix; Huerta-Ramírez, Raúl et al. (2014) Factors associated with suicidal ideation and attempts in Spain for different age groups. Prevalence before and after the onset of the economic crisis. J Affect Disord 163:1-9
Keyes, Katherine M; Pratt, Charissa; Galea, Sandro et al. (2014) The burden of loss: unexpected death of a loved one and psychiatric disorders across the life course in a national study. Am J Psychiatry 171:864-71
Cerdá, Magdalena; Richards, Catherine; Cohen, Greg H et al. (2014) Civilian stressors associated with alcohol use disorders in the National Guard. Am J Prev Med 47:461-6
Karam, Elie G; Friedman, Matthew J; Hill, Eric D et al. (2014) Cumulative traumas and risk thresholds: 12-month PTSD in the World Mental Health (WMH) surveys. Depress Anxiety 31:130-42
Walsh, Kate; Koenen, Karestan C; Aiello, Allison E et al. (2014) Prevalence of sexual violence and posttraumatic stress disorder in an urban African-American population. J Immigr Minor Health 16:1307-10
Roberts, Andrea L; Galea, Sandro; Austin, S Bryn et al. (2014) Women's experience of abuse in childhood and their children's smoking and overweight. Am J Prev Med 46:249-58
Solovieff, Nadia; Roberts, Andrea L; Ratanatharathorn, Andrew et al. (2014) Genetic association analysis of 300 genes identifies a risk haplotype in SLC18A2 for post-traumatic stress disorder in two independent samples. Neuropsychopharmacology 39:1872-9

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