Heterosexual African HIV-1 serodiscordant couples (i.e., one member is HIV-1 infected and the other uninfected) face high risk of HIV-1 transmission and are a priority population for implementing new HIV-1 prevention interventions, given their risk, ability to be targeted for prevention through couples HIV-1 testing, and advantage to the partnership to avert HIV-1 transmission. Robust evidence-based HIV-1 prevention strategies are available for couples, including two powerful interventions that demonstrated high efficacy in clinical trials among couples: antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP). During the current funding cycle of this grant, we conducted high-impact, multidisciplinary work, including novel epidemiologic analyses, mathematical modeling, and social, behavioral, and implementation science to: a) define effective and cost-effective approaches to prioritize delivery of antiretroviral-based prevention to highest- risk couples, b) understand user preferences and facilitators/barriers to use of both ART and PrEP for prevention in this population, and c) pilot an optimized combination prevention package integrating ART and PrEP in a demonstration study among 1000 African couples at four HIV-1 research centers (the Partners Demonstration Project). PrEP and ART were integrated as a package, with PrEP offered prior to ART initiation, including when ART was delayed or declined, and then during the first 6 months after ART start, while achieving viral suppression; we called this the PrEP as a bridge to ART strategy. This intervention resulted in a 96% estimated reduction in HIV-1 transmission. Translating this success to full-scale delivery is needed to move this work to implementation impact. In Kenya, the Ministry of Health has developed an ambitious HIV Prevention Revolution Road Map 2030, in which moving combination biomedical and behavioral prevention interventions for key populations into delivery settings is defined as a national priority. We have assembled a multidisciplinary team, including the Kenya Ministry of Health, to advance pragmatic delivery of ART and PrEP for this key population. We propose to utilize the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) implementation science framework to guide roll-out of PrEP as a bridge to ART for HIV-1 serodiscordant couples in Kenya. We will implement a stepped-wedge trial design to randomly assign 18 HIV-1 care centers to scaled implementation of our PrEP as a bridge to ART strategy.
Our Aims are to evaluate program impact; assess facilitators and barriers to implementation at the health system, organizational, provider, dyadic, and individual levels; and cost and cost-effectiveness of integrated delivery of PrEP and ART.

Public Health Relevance

Heterosexual African HIV-1 serodiscordant couples (i.e., one member is HIV-1 infected and the other uninfected) face high risk of HIV-1 transmission and are a priority population for implementing HIV-1 prevention; during the past five years, we have conducted multidisciplinary HIV-1 prevention studies in which we have shown high acceptability of and adherence to an integrated prevention intervention strategy using antiretroviral medications (antiretroviral treatment [ART] and pre-exposure prophylaxis [PrEP]) among HIV-1 serodiscordant couples, with near-elimination of HIV-1 transmission in a pilot demonstration project. We propose to extend this prior work by conducting a stepped-wedge trial evaluate roll-out of this strategy in public health clinics in Kenya, where policy support for implementing HIV-1 prevention for couples is high.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH095507-06
Application #
9156036
Study Section
Special Emphasis Panel (ZRG1-AARR-N (02)M)
Program Officer
Stirratt, Michael J
Project Start
2011-08-10
Project End
2021-04-30
Budget Start
2016-08-04
Budget End
2017-04-30
Support Year
6
Fiscal Year
2016
Total Cost
$687,244
Indirect Cost
$161,301
Name
University of Washington
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Hancuch, Kerry; Baeten, Jared; Ngure, Kenneth et al. (2018) Safer conception among HIV-1 serodiscordant couples in East Africa: understanding knowledge, attitudes, and experiences. AIDS Care 30:973-981
Pyra, Maria; Brown, Elizabeth R; Haberer, Jessica E et al. (2018) Patterns of Oral PrEP Adherence and HIV Risk Among Eastern African Women in HIV Serodiscordant Partnerships. AIDS Behav :
Mugwanya, Kenneth K; Baeten, Jared M; Wyatt, Christina et al. (2018) Brief Report: Frequency of Monitoring Kidney Function in HIV-Uninfected Persons Using Daily Oral Tenofovir Disoproxil Fumarate Pre-exposure Prophylaxis. J Acquir Immune Defic Syndr 77:206-211
Velloza, Jennifer; Baeten, Jared M; Haberer, Jessica et al. (2018) Effect of Depression on Adherence to Oral PrEP Among Men and Women in East Africa. J Acquir Immune Defic Syndr 79:330-338
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Mugwanya, Kenneth K; Irungu, Elizabeth; Bukusi, Elizabeth et al. (2018) ScaleĀ up of PrEP integrated in public health HIV care clinics: a protocol for a stepped-wedge cluster-randomized rollout in Kenya. Implement Sci 13:118
Heffron, Renee; Mugo, Nelly; Hong, Ting et al. (2018) Pregnancy outcomes and infant growth among babies with in-utero exposure to tenofovir-based preexposure prophylaxis for HIV prevention. AIDS 32:1707-1713
Pyra, Maria; Anderson, Peter L; Hendrix, Craig W et al. (2018) Tenofovir and tenofovir-diphosphate concentrations during pregnancy among HIV-uninfected women using oral preexposure prophylaxis. AIDS 32:1891-1898
Pyra, Maria; Haberer, Jessica E; Heffron, Renee et al. (2018) Brief Report: PrEP Use During Periods of HIV Risk Among East African Women in Serodiscordant Relationships. J Acquir Immune Defic Syndr 77:41-45

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