This project, Empowering Personalized Medicine: Integrating Imaging, Genetics and Biomarkers, responds to RFA-MH-12-020, entitled Integrating Multi-Dimensional Data to Explore Mechanisms Underlying Mental Disorders. By bringing together experts in neuroimaging, genetics, and mathematics, we plan to create an advanced, portable framework to combine diverse biomedical data from 3D neuroimaging (MRI, amyloid/FDG-PET), gene expression networks, genome-wide association studies (GWAS), and other multidimensional data (e.g., physiological biomarkers, epigenetic data, etc.). Our overall goal is to improve diagnosis and prognosis of disease by combining multiple levels of biological information (personalized medicine). In doing so, novel mathematical tools will automatically discover which biomarkers are most helpful in different contexts. To discover and test relationships between very high-dimensional measures (such as images and genomes), we use novel concepts for data reduction such as penalized regression (elastic nets), adaptive hierarchical clustering, Bayesian networks, and support vector machines. Avoiding the limitations of current work that tests individual gene effects independently, we extend the analysis of gene expression networks to images, to relate signs of disease to their genetic underpinnings and to all available biomarkers.
Aim 1 empowers discovery genetic variants (identified in GWAS, whole-exome and whole-genome sequencing) that modulate measures of disease. We will use compressive coding models to discover and verify which sets of genetic variants affect multidimensional images (e.g., co-registered MRI &PET, DTI). We will verify our predictions using k-fold cross-validation and independent replications in new samples and controllable test data.
Aim 2 extends our work using weighted gene co-expression network analysis (WGCNA) from single traits to entire databases of 3D images (MRI/PET). Our framework will merge GWAS, eQTL analysis, and expression-phenotype analysis but will be broadly applicable to any future high-throughput biological information (e.g. methylation profiles, DTI, fMRI).
In Aim 3, we will quantify the added predictive value derivable from genotyping, gene expression profiling, and multimodal neuroimaging for personalized prognosis and diagnosis. For example, which biomarkers (gene expression, CSF, MRI) are most useful in which cases? To maximize impact of this effort, we and our collaborators will test our tools on existing and new datasets from a range of neuropsychiatric disorders including frontotemporal dementia, Alzheimer's disease, schizophrenia, bipolar disorder, and autism (see Support Letters). All tools will be disseminated and linked to web-accessible databases that store and ease access to high-throughput genetic, genomic, and imaging datasets.

Public Health Relevance

Our project improves diagnosis and predictions of patient outcomes by integrating diverse types of patient data including neuroimaging, gene expression profiles, cognitive, and behavioral markers of disease diagnosis, progression, and treatment response. To tackle these complex data types, we develop novel machine learning, network analysis, and database methods. Our personalized medicine approach will help researchers study and evaluate neurological and psychiatric conditions such as Alzheimer's disease, frontotemporal dementia, schizophrenia, bipolar disorder, and autism.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH097268-01
Application #
8304694
Study Section
Special Emphasis Panel (ZMH1-ERB-C (02))
Program Officer
Addington, Anjene M
Project Start
2012-05-01
Project End
2015-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
1
Fiscal Year
2012
Total Cost
$486,695
Indirect Cost
$143,884
Name
University of California Los Angeles
Department
Neurology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Zhang, Guohao; Kochunov, Peter; Hong, Elliot et al. (2017) ENIGMA-Viewer: interactive visualization strategies for conveying effect sizes in meta-analysis. BMC Bioinformatics 18:253
Brouwer, Rachel M; Panizzon, Matthew S; Glahn, David C et al. (2017) Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group. Hum Brain Mapp 38:4444-4458
Roussotte, Florence F; Hua, Xue; Narr, Katherine L et al. (2017) The C677T variant in MTHFR modulates associations between brain integrity, mood, and cognitive functioning in old age. Biol Psychiatry Cogn Neurosci Neuroimaging 2:280-288
Watson, Annie; Pribadi, Mochtar; Chowdari, Kodavali et al. (2016) C9orf72 repeat expansions that cause frontotemporal dementia are detectable among patients with psychosis. Psychiatry Res 235:200-2
Daianu, Madelaine; Mendez, Mario F; Baboyan, Vatche G et al. (2016) An advanced white matter tract analysis in frontotemporal dementia and early-onset Alzheimer's disease. Brain Imaging Behav 10:1038-1053
Adams, Hieab H H (see original citation for additional authors) (2016) Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nat Neurosci 19:1569-1582
Swartz, Elliot W; Baek, Jaeyun; Pribadi, Mochtar et al. (2016) A Novel Protocol for Directed Differentiation of C9orf72-Associated Human Induced Pluripotent Stem Cells Into Contractile Skeletal Myotubes. Stem Cells Transl Med 5:1461-1472
Roussotte, Florence F; Narr, Katherine L; Small, Gary W et al. (2016) The C677T variant in MTHFR modulates associations between blood-based and cerebrospinal fluid biomarkers of neurodegeneration. Neuroreport 27:948-51
Franke, Barbara; Stein, Jason L; Ripke, Stephan et al. (2016) Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nat Neurosci 19:420-431
Daianu, Madelaine; Mezher, Adam; Mendez, Mario F et al. (2016) Disrupted rich club network in behavioral variant frontotemporal dementia and early-onset Alzheimer's disease. Hum Brain Mapp 37:868-83

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