The purpose of this study is to examine whether two transdiagnostic dimensions - reduced reward anticipation (RRA) and heightened sensitivity to potential threat (SPT) - represent risk factors for internalizing (i.e., depression and anxiety) psychopathology. The proposed project is significant because internalizing psychopathologies are very heterogeneous, raising questions as to the validity of the categorical diagnostic nomenclature (e.g., DSM-IV). This study therefore takes the Research Domain Criteria (RDoC) approach and seeks to identify underlying dimensional constructs that cut across traditional categories of psychopathology. However, the proposed project extends the aims of RDoC by examining whether the proposed dimensional constructs reflect 1) risk markers for psychopathology (defining risk via the classic family study method) and 2) separable constructs (i.e., the discriminant validity of RDoC constructs). Specifically, we hypothesize that RRA (but not SPT) will predict risk for depressive symptomatology and SPT (but not RRA) will predict risk for certain anxiety symptoms (e.g., panic). We will recruit 210 probands with a wide range of internalizing psychopathology from the community and assess RRA and SPT using multiple physiological, behavioral, and self-report measures. Our primary indicators of RRA and SPT will be EEG alpha asymmetry while anticipating reward and startle response while anticipating a potential threat, respectively. These psychophysiological variables have been used extensively as measures of RRA and SPT and both tap anticipatory affective states, thus sharpening our test of discriminant validity. In addition, the startle task assesses sensitivity to acute threat a well as potential threat and therefore allows a test of the discriminant validity of RRA and SPT from this third RDoC construct (acute threat). The study aims to examine: 1) whether RRA and SPT predict family history (assessed via direct interview of 1st degree relatives) of separable facets of internalizing psychopathology;2) whether indicators of RRA and SPT are abnormal in 'healthy'(or low symptom) age-matched siblings of probands with high levels of internalizing symptoms;3) the familial aggregation of RRA and SPT;and 4) the construct validity of our electrophysiological measures of RRA and SPT using cardiovascular, behavioral, and self- report indicators of these two constructs. The impact of the study would be in identifying important underlying mechanisms that play a role in the etiopathogeneses of internalizing psychopathology. In addition, if these indicators prove to be familial markers of risk for psychopathology, they would make excellent (and relatively inexpensive) laboratory targets for prevention/early intervention efforts as well as targets for treatment development studies.

Public Health Relevance

The proposed project takes a novel approach to identifying risk factors for internalizing psychopathology (i.e., depression and/or anxiety) by examining whether variation on particular underlying dimensions connote risk for these debilitating and costly conditions. Specifically, this study will examine whether a reduced sensitivity to reward and a heightened sensitivity to threat represent separable dimensions of risk for depression and certain types of anxiety symptoms.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH098093-03
Application #
8670773
Study Section
Special Emphasis Panel (ZMH1)
Program Officer
Kozak, Michael J
Project Start
2012-09-14
Project End
2016-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Illinois at Chicago
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612
Liu, Huiting; Lieberman, Lynne; Stevens, Elizabeth S et al. (2017) Using a cultural and RDoC framework to conceptualize anxiety in Asian Americans. J Anxiety Disord 48:63-69
Sarapas, Casey; Weinberg, Anna; Langenecker, Scott A et al. (2017) Relationships among attention networks and physiological responding to threat. Brain Cogn 111:63-72
Gorka, Stephanie M; Lieberman, Lynne; Shankman, Stewart A et al. (2017) Startle potentiation to uncertain threat as a psychophysiological indicator of fear-based psychopathology: An examination across multiple internalizing disorders. J Abnorm Psychol 126:8-18
Lieberman, Lynne; Stevens, Elizabeth S; Funkhouser, Carter J et al. (2017) How many blinks are necessary for a reliable startle response? A test using the NPU-threat task. Int J Psychophysiol 114:24-30
Stevens, Elizabeth S; Weinberg, Anna; Nelson, Brady D et al. (2017) The effect of panic disorder versus anxiety sensitivity on event-related potentials during anticipation of threat. J Anxiety Disord 54:1-10
Weinberg, Anna; Shankman, Stewart A (2017) Blunted reward processing in remitted melancholic depression. Clin Psychol Sci 5:14-25
Shankman, Stewart A; Funkhouser, Carter J; Klein, Daniel N et al. (2017) Reliability and validity of severity dimensions of psychopathology assessed using the Structured Clinical Interview for DSM-5 (SCID). Int J Methods Psychiatr Res :
Gorka, Stephanie M; Shankman, Stewart A (2017) Preliminary evidence that reactivity to uncertain threat is an endophenotype for alcohol use disorder. Drug Alcohol Depend 180:265-271
Lieberman, Lynne; Liu, Huiting; Huggins, Ashley A et al. (2016) Comparing the validity of informant and self-reports of personality using laboratory indices of emotional responding as criterion variables. Psychophysiology 53:1386-97
Gorka, Stephanie M; Lieberman, Lynne; Phan, K Luan et al. (2016) Association between problematic alcohol use and reactivity to uncertain threat in two independent samples. Drug Alcohol Depend 164:89-96

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