We request administrative supplemental funding to support the enrollment, inclusion, and molecular analyses of a total of 295 African-American families at two new point-of-care facilities affiliated with the Emory site of this network --the Marcus Autism Center Diagnostics Program (located in the same building as the Marcus Autism Center/Emory research program) and Hughes Spalding Children?s Hospital (located six miles away) -- over three years (Years 2-4) of our current UCLA-led ACE Network. We anticipate that this additional recruitment (an increase of 42% overall) will (a) increase power of hypothesis-testing in all Aims of the project, (b) increase socio- economic diversity and representability of the African-American population, particularly of its low-income subsections (a critical goal given hypotheses tested in Aim 2 and in light of recent health disparity findings), and (c) set the foundation for additional community engagement and subsequent minority African-American subject recruitment for this study and for other network studies in the future. !
The current project (as funded for the next four years) provides for enrollment of 698 new African-American (AA) probands and their families across four recruitment sites. We are requesting supplemental funds to recruit and perform molecular analyses for an additional 295 families in the Atlanta, GA area, bringing the total number of families recruited to 993 (an increase of 42%) over three years. Recruitment will be performed in a manner that considerably broadens the socio-economic diversity of AA families enrolled to include families at point-of-care for clinical services affiliated with the Emory site, including, importantly, a community-based facility.
|Cantor, R M; Navarro, L; Won, H et al. (2018) ASD restricted and repetitive behaviors associated at 17q21.33: genes prioritized by expression in fetal brains. Mol Psychiatry 23:993-1000|
|Kopp, Nathan D; Parrish, Phoebe C R; Lugo, Michael et al. (2018) Exome sequencing of 85 Williams-Beuren syndrome cases rules out coding variation as a major contributor to remaining variance in social behavior. Mol Genet Genomic Med 6:749-765|
|Gandal, Michael J; Zhang, Pan; Hadjimichael, Evi et al. (2018) Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science 362:|
|Parras, Alberto; Anta, Héctor; Santos-Galindo, María et al. (2018) Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing. Nature 560:441-446|
|Gandal, Michael J; Haney, Jillian R; Parikshak, Neelroop N et al. (2018) Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science 359:693-697|
|de la Torre-Ubieta, Luis; Stein, Jason L; Won, Hyejung et al. (2018) The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis. Cell 172:289-304.e18|
|Dougherty, Joseph D; Yang, Chengran; Lake, Allison M (2017) Systems biology in the central nervous system: a brief perspective on essential recent advancements. Curr Opin Syst Biol 3:67-76|
|O'Connor, Shawn David; Cabrera, Omar Hoseá; Dougherty, Joseph D et al. (2017) Dexmedetomidine protects against glucocorticoid induced progenitor cell apoptosis in neonatal mouse cerebellum. J Matern Fetal Neonatal Med 30:2156-2162|
|Watanabe, Momoko; Buth, Jessie E; Vishlaghi, Neda et al. (2017) Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. Cell Rep 21:517-532|
|Ellis, Shannon E; Gupta, Simone; Moes, Anna et al. (2017) Exaggerated CpH methylation in the autism-affected brain. Mol Autism 8:6|
Showing the most recent 10 out of 49 publications