Biofeedback of real-time functional magnetic resonance imaging (rt-fMRI) data is a new technique in which the activity in a specific region of a subject's brain is provided as a feedback signal to the subject. The subject can experiment with different cognitive strategies to identify those that are effective in influencing brain activty in the region of interest. By practicing those strategies and monitoring their success, subjects can train themselves to control the target brain region. The proposed research project applies this technique to obsessive-compulsive disorder (OCD). More specifically, the project examines whether biofeedback of rt-fMRI data can enable individuals with OCD to develop control over activity in a region of their orbitofrontal cortex involved in symptom anxiety and thereby reduce their obsessive-compulsive symptoms. If so, this new technique may yield a low-risk, non-invasive clinical intervention for OCD. In addition, patterns of resting state functional connectivty between brain areas will be examined before and after biofeedback to determine how intrinsic brain dynamics are altered by the intervention, and how those alterations relate to changes in clinical symptoms. This will inform our understanding of the network dynamics underlying obsessive-compulsive symptoms. Although this research project is focused on developing a protocol specifically for treating and studying OCD, the methodology has great promise as both a treatment intervention and a research tool for a broad range of neuropsychiatric disorders.

Public Health Relevance

Real-time brain imaging can provide information regarding activity in a specific brain area as it changes over time. By providing individuals with obsessive-compulsive disorder (OCD) with this information as a feedback signal, we will train them to control neural activity in their orbitofrontal cortex and examine how that training affects their symptoms and their brain function. Although the proposed research develops and applies this method specifically to the treatment and study of OCD, the method has potential therapeutic and investigative utility for a wide range of mental disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH100068-01A1
Application #
8772084
Study Section
Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section (NPAS)
Program Officer
Rumsey, Judith M
Project Start
2014-09-04
Project End
2019-06-30
Budget Start
2014-09-04
Budget End
2015-06-30
Support Year
1
Fiscal Year
2014
Total Cost
$540,909
Indirect Cost
$216,039
Name
Yale University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520