Interactions between the amygdala and the hippocampal memory system are thought to be important for the memory enhancement that can result from moderate emotional arousal and for the memory dysfunction that can result from extreme emotional arousal, such as what occurs in post-traumatic stress disorder. Direct activation of the basolateral complex of the amygdala (BLA) in rats can enhance memory for both emotional and neutral events, suggesting that amygdala-hippocampal interactions wield a generalized memory- enhancing capacity. Thus, understanding how direct BLA activation impacts the hippocampal memory system will be fundamental to understanding basic mechanisms of endogenous memory enhancement and will be relevant to memory dysfunction in affective disorders. Over the five-year period, the proposed experiments are expected to contribute to the training of one postdoctoral fellow, two doctoral students, and five undergraduate students.

Public Health Relevance

The objective of the proposal is to understand how the functional connectivity between the amygdala and the hippocampal memory system is used to prioritize memories. The project is relevant to disorders of memory and to disorders involving affect, including post-traumatic stress disorder.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH100318-03
Application #
9179662
Study Section
Neurobiology of Learning and Memory Study Section (LAM)
Program Officer
Buhring, Bettina D
Project Start
2014-12-01
Project End
2019-11-30
Budget Start
2016-12-01
Budget End
2017-11-30
Support Year
3
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Emory University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Manns, Joseph R; Bass, David I (2016) The amygdala and prioritization of declarative memories. Curr Dir Psychol Sci 25:261-265
Depp, Colin A; Dev, Sheena; Eyler, Lisa T (2016) Bipolar Depression and Cognitive Impairment: Shared Mechanisms and New Treatment Avenues. Psychiatr Clin North Am 39:95-109
Bass, David I; Manns, Joseph R (2015) Memory-enhancing amygdala stimulation elicits gamma synchrony in the hippocampus. Behav Neurosci 129:244-56