The application proposes to examine the domain of Perception as applied to young infants. P50 sensory gating will be utilized as the primary measure of Perception. Three approaches will be utilized: (1) Examine if infant P50 sensory gating is predictive of 4 year-old behavior;(2) Examine if infant P50 sensory gating is related to 4 year-old measures of Perception, Attention, and Cognitive Control;and (3) Identify the neural correlates of infant P50 sensory gating utilizing fMRI. This work should help to clarify the validiy of the RDoC classification system in young infants.

Public Health Relevance

P50 sensory gating, a biomarker for perception, has been linked, in adults to neurocognitive, and in particular, cognitive control performance. While P50 sensory gating can be assessed in young infants, little is known about (a) whether this very early assessment is associated with childhood cognitive control performance, nor (b) the neural correlates of P50 sensory gating in this age range. This proposal seeks to evaluate the early childhood relationship between perception and cognitive control by (1) examining the relationship between infant P50 sensory gating and four-year-old measures of perception, cognitive control, and attention and (2) utilizing fMRI to examine resting state activity in relevat brain regions including dorsolateral prefrontal cortex.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
3R01MH101295-02S1
Application #
8903938
Study Section
Special Emphasis Panel (ZMH1-ERB-S (04))
Program Officer
Friedman-Hill, Stacia
Project Start
2013-08-01
Project End
2017-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
2
Fiscal Year
2014
Total Cost
$44,824
Indirect Cost
$15,905
Name
University of Colorado Denver
Department
Psychiatry
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045