HIV transmission can be decreased substantially by reducing the proportion of undiagnosed infections and expanding early and consistent use of antiretroviral therapy (ART). In fact, Treatment as Prevention (TasP) has been proposed as key to ending the HIV epidemic. To activate TasP in high prevalence countries, like South Africa, communities must be motivated to know their status, engage in care, and remain in care - community mobilization (CM) is needed. CM has the potential to significantly increase uptake testing, linkage to and retention in care, essential to population level declines in HIV by addressing the primary social barriers to engagement with the HIV care system. CM strategies for linkage and retention have not yet been rigorously evaluated despite their promise. To address this gap, we aim to implement and evaluate a theory-based CM intervention addressing known social barriers to engagement in care with the aim of increasing HIV testing uptake, thereby decreasing undiagnosed infections (aims 1), improving linkage to care (aim 2), and increasing retention in care (aim 3) in rural South Africa, while also exploring the mechanisms through which CM improves outcomes along the care cascade (aim 4). The CM intervention will be evaluated by comparing gains in testing, linkage, and retention in care in 16 intervention na?ve communities (8 intervention and 8 control) within a health and demographic surveillance site (HDSS) in rural Mpumalanga province, South Africa. The CM intervention is based on four years of formative social science research and two years of implementation experience in the area utilizing the same conceptual model developed by our team. The intervention activities map onto six domains of CM that must be addressed for CM to successfully occur: 1) development of a shared concern around TasP;2) community sensitization or building of critical consciousness;3) an organizational structure to links to groups/networks in supporting TasP;4) leadership;5) collective activities/actions;and 6) community cohesion. Mobilization activities include pilot-tested strategies and will be carried out by our implementing partner, Sonke Gender Justice. To measure rates of testing, linkage and retention, we will link an existing electronic clinical tracking system in use in all clinics in the HDSS to the longitudinal HDSS census data. This provides a unique opportunity to establish an open, population-based cohort with over 30,000 18-49 year old residents. Merging census and clinical data allows us to simultaneously evaluate the effects of our intervention and to characterize the HIV care cascade in a high prevalence population. In addition, we will evaluate CM processes by conducting community based surveys to monitor intervention exposure and community level change using validated measures of CM. This proposal builds on our teams experience with CM in the study area and a strong team of partners-we are well positioned to conduct a rigorously designed and evaluated trial to determine the impact of CM on the care cascade, helping to fill an urgent need.

Public Health Relevance

Significant improvement in uptake of HIV testing, linkage to and retention in HIV care are critical to turning the tide on the HIV epidemic - community mobilization has tremendous potential to address the major social barriers to successful participation in the HIV care cascade. We will implement and evaluate a community- level, theory-based mobilization intervention to decrease undiagnosed infections and improve linkage and retention in care in a high prevalence setting in South Africa. Rigorous evaluation of this model, using a community, cluster randomized trial design and longitudinal measurement of community mobilization domains, will permit identification of the specific mechanisms of effect and contribute to more effective program planning in high incidence settings.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH103198-01A1
Application #
8790384
Study Section
Behavioral and Social Consequences of HIV/AIDS Study Section (BSCH)
Program Officer
Gordon, Christopher M
Project Start
2014-08-15
Project End
2019-07-31
Budget Start
2014-08-15
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
$667,828
Indirect Cost
$185,514
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143