Although epigenetic regulation of gene expression has been shown to be associated with experience- dependent neural plasticity and memory formation, due to technical and conceptual limitations, the full repertoire of DNA base modifications and their role in neuropsychiatric disease remains equivocal. In this project, new technology will be developed to more precisely identify activity-dependent epigenetic mechanisms in neuronal populations selectively activated by learning and challenge current concepts related to the full repertoire of DNA base modifications and their role in regulating gene expression. Specifically, we will determine whether there is a causal relationship between various DNA base modifications and rapid behavioral adaptation, and we will advance the state of knowledge regarding the molecular mechanisms underlying the memory in a preclinical model of fear-related anxiety disorder.

Public Health Relevance

By developing new technology to simultaneously identify and characterize the role of experience-dependent modification of DNA in the regulation of gene expression underlying the formation fear-related memories in a preclinical model of neuropsychiatric disorder, the findings of the experiments outlined in this application will open up entirely new directions for research in cognitive neuroepigenetics, and may have broad translational implications by establishing novel epigenetic targets for therapeutic intervention in fear-related anxiety disorders.

Agency
National Institute of Health (NIH)
Type
Research Project (R01)
Project #
1R01MH105398-01
Application #
8799136
Study Section
Special Emphasis Panel (ZMH1)
Program Officer
Beckel-Mitchener, Andrea C
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Other Basic Sciences
Type
Schools of Arts and Sciences
DUNS #
City
Irvine
State
CA
Country
United States
Zip Code
92697