Deficient control and monitoring of memory processes is a key feature of major psychiatric diseases, including schizophrenia, bipolar disorder, and PTSD. The long-term goal of this research is to understand how individual brain areas within the temporal-and frontal lobes interact, how these interactions are coordinated and how disruption of such coordination results in mental disease. The proposed experiments will utilize rare neurosurgical opportunities to directly record from individual neurons in several areas of the human medial frontal cortex and the hippocampus to study the role of theta-mediated coordination in the executive control of memory. This approach is motivated by previous work from this laboratory, which has revealed a candidate microcircuit for declarative memories consisting of groups of cells that signal memory strength and a second group that signals highly processed sensory information independent of memories (VS/MS neurons). The overall objective of this application is to understand how information provided by these hippocampal neurons is utilized by areas in the medial frontal lobes to make decisions and how such memory-based decision making processes are monitored and controlled. We will achieve this objective by recording single-neurons from the hippocampus and three medial frontal cortical areas important for monitoring and control of memory processes: the ACC, pre-SMA, and vmPFC. Our central hypothesis is that Frontal-Hippocampal coordination is mediated by theta-band oscillations such that subsets of medial frontal neurons transiently phase-lock to hippocampal theta oscillations in order to gain access to task-relevant information provided by subsets of VS/MS neurons in the hippocampus.
Our specific aims are to determine how medial frontal neurons accumulate evidence provided by the hippocampus (Aim 1), to determine whether medial frontal neurons exert top-down control over the hippocampus (Aim 2), and to test the causality of theta-mediated medial frontal- hippocampal coordination for memory (Aim 3). The contribution is significant because it will provide an unprecedented characterization of the role of medial frontal-hippocampal coordination in the control of memory processes through bottom-up and top-down interactions and their causal necessity. The approach is innovative because we directly test, in humans, a hypothesis of high significance for psychiatric disease which cannot be tested by non-invasive fMRI/EEG/MEG studies nor by animal models due to the unclear homologies of frontal areas. The work proposed in this application will advance knowledge on the normal mechanisms of frontal- temporal coordination by theta oscillations and might thereby enable the development of new treatments to restore or improve such coordination in cases of mental disease.

Public Health Relevance

Psychiatric diseases such as schizophrenia, bipolar disorder, and PTSD often result in significant and life-long memory deficits, but few options exist to resolve the accompanying problems in remembering and recalling information. The goal of this research is to develop a better understanding of the processes in the human brain by which long-term memory processes are controlled and guided. This is important, because it is these control processes which are deficient in psychiatric disease, and developing strategies to restore their normal function is therefore a promising potential new treatment strategy that this research might enable.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH110831-02
Application #
9324359
Study Section
Special Emphasis Panel (ZMH1)
Program Officer
Buhring, Bettina D
Project Start
2016-08-01
Project End
2021-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
2
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048
Wang, Shuo; Yu, Rongjun; Tyszka, J Michael et al. (2017) The human amygdala parametrically encodes the intensity of specific facial emotions and their categorical ambiguity. Nat Commun 8:14821
Minxha, Juri; Mosher, Clayton; Morrow, Jeremiah K et al. (2017) Fixations Gate Species-Specific Responses to Free Viewing of Faces in the Human and Macaque Amygdala. Cell Rep 18:878-891
Reed, Chrystal M; Birch, Kurtis G; Kami?ski, Jan et al. (2017) Automatic detection of periods of slow wave sleep based on intracranial depth electrode recordings. J Neurosci Methods 282:1-8
Kami?ski, Jan; Sullivan, Shannon; Chung, Jeffrey M et al. (2017) Persistently active neurons in human medial frontal and medial temporal lobe support working memory. Nat Neurosci 20:590-601