This project is focused on determining how best to use sleep as an intervention to promote recovery from the biobehavioral risks posed by chronic sleep restriction. Chronic partial sleep loss due to medical conditions and social demands is common and associated with significant clinical morbidity. Our studies have shown that chronic restriction of sleep to between 4h and 6h per night results in neurobehavioral deficits that accumulate to levels equivalent to those produced by total sleep loss. We will undertake the first research to determine what aspects of sleep are critical for recuperation from the effects of chronic partial sleep loss. The issue of recovery of waking neurobehavioral and physiological functions will be addressed using an experimental approach that systematically determines the recovery potential of sleep in 180 healthy female (n=90) and male (n=90) subjects. Sleep duration will be varied parametrically on two consecutive nights, following 5 days of chronic sleep restriction. Key aspects of waking biobehavioral functions sensitive to sleep loss will be measured in subjects randomized to one of six sleep durations on recovery night 1 and one of six sleep durations on recovery night 2 (i.e., a total of 36 different combinations of sleep across the two nights). Statistically efficient response-surface modeling and dose-response regression approaches will be used for mapping recovery in neurocognitive, mood, and physiological outcomes as a function of sleep, using time in bed, total sleep time, and specific sleep physiological measures (e.g., REM sleep, slow wave energy in non- REM sleep) as independent variables. The resulting response-surface maps and dose-response curves will reveal the degree of recuperation of biobehavioral functions relative to varying amounts and types of sleep. These approaches also provide estimates of the variance attributable to gender differences, age effects, and differences in habitual sleep duration at home. The empirically estimated response-surface maps will be compared to predictions inferred from current biomathematical models of sleep-wake regulation, to assess how well these models predict recovery gained from sleep of different durations. In addition to providing the first dose-response curves for the relationship of sleep duration to recovery of waking functions, this project will explore the effects of varying sleep durations on cardiovascular markers in both women and men. The scientific data to be generated will advance theoretical understanding of sleep homeostasis; improve mathematical models of sleep-wake regulation; and inform questions of sleep need relative to public health. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Research Project (R01)
Project #
5R01NR004281-10
Application #
6889270
Study Section
Special Emphasis Panel (ZRG1-RPHB-2 (01))
Program Officer
Marden, Susan F
Project Start
1995-09-30
Project End
2009-01-31
Budget Start
2005-02-01
Budget End
2006-01-31
Support Year
10
Fiscal Year
2005
Total Cost
$634,542
Indirect Cost
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Dennis, Laura E; Wohl, Rachael J; Selame, Lauren A et al. (2017) Healthy Adults Display Long-Term Trait-Like Neurobehavioral Resilience and Vulnerability to Sleep Loss. Sci Rep 7:14889
Spaeth, Andrea M; Dinges, David F; Goel, Namni (2017) Objective Measurements of Energy Balance Are Associated With Sleep Architecture in Healthy Adults. Sleep 40:
Basner, Mathias; Dinges, David F; Shea, Judy A et al. (2017) Sleep and Alertness in Medical Interns and Residents: An Observational Study on the Role of Extended Shifts. Sleep 40:
Zhang, Shirley L; Bai, Lei; Goel, Namni et al. (2017) Human and rat gut microbiome composition is maintained following sleep restriction. Proc Natl Acad Sci U S A 114:E1564-E1571
Perlis, Michael L; Grandner, Michael A; Chakravorty, Subhajit et al. (2016) Suicide and sleep: Is it a bad thing to be awake when reason sleeps? Sleep Med Rev 29:101-7
Perlis, Michael L; Grandner, Michael A; Brown, Gregory K et al. (2016) Nocturnal Wakefulness as a Previously Unrecognized Risk Factor for Suicide. J Clin Psychiatry 77:e726-33
Patel, Viral C; Spaeth, Andrea M; Basner, Mathias (2016) Relationships between time use and obesity in a representative sample of Americans. Obesity (Silver Spring) 24:2164-75
Weljie, Aalim M; Meerlo, Peter; Goel, Namni et al. (2015) Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt. Proc Natl Acad Sci U S A 112:2569-74
Fang, Zhuo; Spaeth, Andrea M; Ma, Ning et al. (2015) Altered salience network connectivity predicts macronutrient intake after sleep deprivation. Sci Rep 5:8215
Spaeth, Andrea M; Dinges, David F; Goel, Namni (2015) Resting metabolic rate varies by race and by sleep duration. Obesity (Silver Spring) 23:2349-56

Showing the most recent 10 out of 80 publications