Because methods have yet to be developed to integrate findings across qualitative and quantitative studies, the evidence base for practice has yet to reflect all of the best evidence. Accordingly, the immediate aim of the proposed study is to develop methods to conduct mixed research integration studies. This is essential to facilitate the appropriate utilization in practice of all kinds of empirical research findings and to expand the methodological options available to accommodate disparate sources of evidence. Empirical research with findings pertaining to stigma and to adherence to antiretroviral therapy in HIV-positive women will be used to accomplish the objectives of the study, which are to: (a) clarify the relationships between qualitative and quantitative research findings in common research areas; (b) develop research designs for mixed research integration studies that accommodate these relationships, especially the heterogeneity across studies; (c) develop analytic techniques to link or transform qualitative and quantitative research findings for combination; and (d) produce credible and usable integrations of findings. All channels of communication will be used to conduct a comprehensive high-recall search of the literature. Reports retrieved will be appraised and compared for their informational content and formal properties. Among the specific methods that will be used are Ragin's comparative case analysis and Bayesian approaches to meta-analysis. The material outcomes of the project will include: (a) guidelines for conducting mixed research integration studies; (b) a set of procedures and tools to appraise, evaluate, classify, and combine findings in methodologically disparate studies; and (c) a set of research integrations produced from the methods developed in the project. This study is a continuation of the NINR/NIH study, """"""""Analytic techniques for qualitative metasynthesis"""""""" (NR04907 & NR04907S, 06/01/00-02/28/05). This study is also in response to PA- 02-072, Methodology and Measurement in the Behavioral and Social Sciences, and addresses priorities in the NIH Roadmap initiative pertaining to the development of innovative methodologies and priorities in the Fiscal Year 2004 Plan for HIV-Related Research. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Research Project (R01)
Project #
2R01NR004907-06
Application #
6924219
Study Section
Nursing Science: Adults and Older Adults Study Section (NSAA)
Program Officer
Hare, Martha L
Project Start
2000-06-01
Project End
2010-03-31
Budget Start
2005-06-03
Budget End
2006-03-31
Support Year
6
Fiscal Year
2005
Total Cost
$317,488
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
Schools of Nursing
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Sandelowski, Margarete; Voils, Corrine I; Leeman, Jennifer et al. (2012) Mapping the Mixed Methods-Mixed Research Synthesis Terrain. J Mix Methods Res 6:317-331
Voils, Corrine I; Chang, Yunkyung; Crandell, Jamie et al. (2012) Informing the dosing of interventions in randomized trials. Contemp Clin Trials 33:1225-30
Voils, Corrine I; Crandell, Jamie L; Chang, YunKyung et al. (2011) Combining adjusted and unadjusted findings in mixed research synthesis. J Eval Clin Pract 17:429-34
Crandell, Jamie L; Voils, Corrine I; Chang, Yunkyung et al. (2011) Bayesian data augmentation methods for the synthesis of qualitative and quantitative research findings. Qual Quant 45:653-669
Leeman, Jennifer; Chang, Yunkyung; Voils, Corrine I et al. (2011) A mixed-methods approach to synthesizing evidence on mediators of intervention effects. West J Nurs Res 33:870-900
Leeman, Jennifer; Chang, Yun Kyung; Lee, Eun Jeong et al. (2010) Implementation of antiretroviral therapy adherence interventions: a realist synthesis of evidence. J Adv Nurs 66:1915-30
Sandelowski, Margarete; Barroso, Julie; Voils, Corrine I (2009) Gender, race/ethnicity, and social class in research reports on stigma in HIV-positive women. Health Care Women Int 30:273-88
Sandelowski, Margarete; Voils, Corrine I; Chang, Yunkyung et al. (2009) A systematic review comparing antiretroviral adherence descriptive and intervention studies conducted in the USA. AIDS Care 21:953-66
Chang, YunKyung; Voils, Corrine I; Sandelowski, Margarete et al. (2009) Transforming verbal counts in reports of qualitative descriptive studies into numbers. West J Nurs Res 31:837-52
Voils, Corrine; Hassselblad, Vic; Crandell, Jamie et al. (2009) A Bayesian method for the synthesis of evidence from qualitative and quantitative reports: the example of antiretroviral medication adherence. J Health Serv Res Policy 14:226-33

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