Patients with acute coronary syndromes (ACS) with depression are at greater risk for subsequent major adverse coronary events (MACE: myocardial infarctions, revascularization procedures, strokes, and death). Depressive symptoms are associated with increased inflammatory protein levels, but only in certain individuals. Proposed is to test if inflammatory protein gene polymorphisms interact with depression resulting in even greater increases in inflammatory protein levels than those caused by either gene polymorphisms or depression alone, increasing risk of subsequent MACE.
Specific aims are to determine 1) whether depression is associated with the risk of MACE; 2) whether inflammatory protein levels during ACS differ between those with and without depression; 3) whether selected genetic polymorphisms are related to the level of inflammatory proteins; 4) whether genetic polymorphisms and depressive symptoms interact to influence the level of inflammatory proteins; and 5) and whether genetic polymorphisms and depressive symptoms interact to influence risk of MACE. Inflammatory proteins and genes include: Interleukin (IL) 6, C-reactive protein (CRP), Tumor Necrosis Factor Alpha (TNFa), E-Selectin (SELE) and Monocyte Chemoattractant Protein-1 (MCP-1). From about 1300 ACS patients, blood samples for genetic and protein work will be collected once shortly after hospital admission before cardiac intervention, and depression will be assessed once within 2-5 days post admission. Occurrence of MACE will be followed for 2 years. Data will be analyzed using logistic regression and survival analysis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Research Project (R01)
Project #
7R01NR010235-06
Application #
8462084
Study Section
Nursing Science: Adults and Older Adults Study Section (NSAA)
Program Officer
Huss, Karen
Project Start
2007-09-29
Project End
2014-01-31
Budget Start
2012-05-11
Budget End
2014-01-31
Support Year
6
Fiscal Year
2011
Total Cost
$324,013
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Type
Schools of Nursing
DUNS #
122452563
City
Little Rock
State
AR
Country
United States
Zip Code
72205
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Yammine, Luba; Frazier, Lorraine; Padhye, Nikhil S et al. (2014) Severe depressive symptoms are associated with elevated endothelin-1 in younger patients with acute coronary syndrome. J Psychosom Res 77:430-4
Sanner, J E; Frazier, L; Udtha, M (2013) Self-reported depressive symptoms in women hospitalized for acute coronary syndrome. J Psychiatr Ment Health Nurs 20:913-20
Sanner, Jennifer E; Frazier, Lorraine; Udtha, Malini (2013) The role of platelet serotonin and depression in the acute coronary syndrome population. Yale J Biol Med 86:5-13
Sanner, Jennifer E; Frazier, Lorraine; Udtha, Malini (2013) Effects of delayed laboratory processing on platelet serotonin levels. Biol Res Nurs 15:13-6
Yammine, Luba; Frazier, Lorraine (2013) Comparison of demographic, psychosocial, and clinical characteristics among younger and older persons with acute coronary syndrome. J Am Assoc Nurse Pract 25:103-8
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Virani, Salim S; Brautbar, Ariel; Lee, Vei-Vei et al. (2011) Usefulness of single nucleotide polymorphism in chromosome 4q25 to predict in-hospital and long-term development of atrial fibrillation and survival in patients undergoing coronary artery bypass grafting. Am J Cardiol 107:1504-9
Frazier, Lorraine; Vaughn, William K; Willerson, James T et al. (2009) Inflammatory protein levels and depression screening after coronary stenting predict major adverse coronary events. Biol Res Nurs 11:163-73

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