With funding from the National Institute of Nursing Research (Distribution of the Costs of Antimicrobial Resistant Infections, R01 NR010822), we have developed a database of >319,000 patient discharges from four urban (Manhattan) hospitals for the years 2006-8. This database has been used to answer a variety of clinical questions regarding healthcare-associated infections (HAI), but to continue to be useful and relevant;we have expanded and integrated the database as a targeted research data registry into the Clinical Data Warehouse of a large health care system. The data will continue to be updated and sustained so that trends over years can be tracked.
Specific aims of this competitive renewal are to conduct three comparative effectiveness research (CER) studies on data from 2006-2012 to: (1) evaluate the effectiveness of adherence to transmission-based isolation precautions for preventing the spread of infections in acute care settings using transmission visualization techniques;(2) examine the impact of nursing organizational factors (e.g., staffing, skill mix, turnover) on rates and types of HAI among hospitalized patients;and (3 compare the effectiveness of universal contact precautions with standard practice in intensive care units (ICUs) to reduce rates of acquisition and infection caused by multidrug-resistant organisms (MDROs) and Clostridium difficile. In addition, as part of our Data Sharing Plan we propose to develop and/or adopt the following policies and procedures: data contributor and user agreements and data stewardship policies (right of first use, institutional and data confidentiality and protection, quality of the research, monitoring and integrity of data management) which will contribute to the burgeoning science of data governance. We will then make the registry more widely available to researchers for other CER project to assess practices to reduce HAI.

Public Health Relevance

Health information technology holds great promise for improving coordination and standardization of clinical care and health outcomes for individual patients and across health care settings, but its potential is yet to be fulfilled. Using data from >600,000 patient discharges, we propose to examine the effectiveness of various practices aimed at reducing healthcare-associated infections.

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Research Project (R01)
Project #
5R01NR010822-07
Application #
8631099
Study Section
Nursing and Related Clinical Sciences Study Section (NRCS)
Program Officer
Hardy, Lynda R
Project Start
2007-09-28
Project End
2015-12-31
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
7
Fiscal Year
2014
Total Cost
$327,823
Indirect Cost
$118,097
Name
Columbia University (N.Y.)
Department
None
Type
Schools of Nursing
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Faleck, David M; Salmasian, Hojjat; Furuya, E Yoko et al. (2016) Proton Pump Inhibitors Do Not Increase Risk for Clostridium difficile Infection in the Intensive Care Unit. Am J Gastroenterol 111:1641-1648
Tchakoute, Christophe Toukam; Larson, Elaine; Liu, Jianfang et al. (2016) Risk factors and temporal trends of hospital-acquired infections (HAIs) among HIV positive patients in urban New York City hospitals: 2006 to 2014. Rev Recent Clin Trials :
Yoon, Sunmoo; Cohen, Bevin; Cato, Kenrick D et al. (2016) Visualization of Data Regarding Infections Using Eye Tracking Techniques. J Nurs Scholarsh 48:244-53
Baker, P; Cohen, B; Liu, J et al. (2016) Incidence and risk factors for community-associated methicillin-resistant Staphylococcus aureus in New York City, 2006-2012. Epidemiol Infect 144:1014-7
Chen, Yingxue; Liu, Jianfang; Larson, Elaine (2016) Temporal trends and factors associated with pediatric hospitalizations with respiratory infection. J Asthma 53:15-8
Park, Sun O; Liu, Jianfang; Furuya, E Yoko et al. (2016) Carbapenem-Resistant Klebsiella pneumoniae Infection in Three New York City Hospitals Trended Downwards From 2006 to 2014. Open Forum Infect Dis 3:ofw222
Hessels, Amanda J; Agarwal, Mansi; Liu, Jianfang et al. (2016) Incidence and Risk Factors for Health-Care Associated Infections after Hip Operation. Surg Infect (Larchmt) 17:761-765
Glied, Sherry; Cohen, Bevin; Liu, Jianfang et al. (2016) Trends in mortality, length of stay, and hospital charges associated with health care-associated infections, 2006-2012. Am J Infect Control 44:983-9
Monteserin, N; Larson, E (2016) Temporal trends and risk factors for healthcare-associated vancomycin-resistant enterococci in adults. J Hosp Infect 94:236-241
Kovacikova, Zuzana; Neumannova, Katerina; Bizovska, Lucia et al. (2016) Postural stability in school-age children with mild bronchial asthma disease (a pilot study). J Asthma 53:11-4

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