This resubmission of a NEW INVESTIGATOR led longitudinal study is in response to (PA-11-104) and will examine: (1) the impact of (GXE) genetic and psychological environmental factors (discrimination, depression, and parenting behaviors) on the health of African American (AA) children aged 3 through 5 years and (2) the GXE risk for hypertension (HTN) in AA women and children. The overall goal of this project is to delineate the psychobiological (GXE interaction) mechanisms through which AA mothers' perceived racial discrimination, mental health, and parenting behavior affect their own and their young children's blood pressure (BP) over time. Our research will examine both genetic (candidate gene and epigenetic effects) and psychological (maternal perceived racial discrimination, mental health, and parenting behavior) interaction effects on BP on this population. We will employ a psychobiological approach by: utilizing psychological and biological assessments using a longitudinal cohort research design, a 2-step candidate gene and epigenetic methodology, and use of ancestry informative markers to account for population stratification admixture to explore GXE interactions on BP in AA mothers and children. Data analysis for the study will be conducted using multiple mixed modeling, cross-validation, and false discovery rate methods. We will enroll 250 AA children aged 3 through 5 years and their (n=250) mothers/maternal caregivers. We will assess mother and child factors every six months for 2 years. We propose the following:
Aim 1 : Examine the GXE interaction and epigenetic effects of mothers' perceived racial discrimination and its influence on BP over a period of two years.
Aim 2 : Examine the GXE interaction and epigenetic effects of mothers' mental health status [symptoms of depression] and its influence on BP over a period of two years.
Aim 3 : Examine the GXE interaction and epigenetic effects of mothers' parenting behavior and its influence on BP over a period of two years. Our project supports NINR's mission to promote and improve the health of individuals, families, communities, and populations by conducting basic research on the health and illness of women and young children. The proposed research extends nursing science by integrating the biological (genetics) and behavioral (psychology) components that can inform the combination of multi-level factors that contribute to AAs having the highest incidence of HTN in the US. Findings from our project can contribute to developing interventions that address genetic and psychological factors to reduce these risks for HTN.

Public Health Relevance

The proposed study is relevant for several reasons; first, it will investigate the combined association of genomic and psychological environmental effects on predicting high blood pressure and thus add to the body of knowledge of gene-environment interactions for hypertension among African American mothers and children. Second, our findings will also shed light on epigenetic and psychological environmental factors affecting blood pressure in this population. Finally, the proposed study will expand our understanding of how parenting stress and parenting style impact parents and children's blood pressure thus providing critical insights into in reducing hypertension health disparities among African American mothers and children.

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Research Project (R01)
Project #
5R01NR013520-04
Application #
9293132
Study Section
Health Disparities and Equity Promotion Study Section (HDEP)
Program Officer
Tully, Lois
Project Start
2014-09-01
Project End
2017-12-31
Budget Start
2017-07-01
Budget End
2017-12-31
Support Year
4
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Nursing
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Huang, Yunfeng; Hui, Qin; Walker, Douglas I et al. (2018) Untargeted metabolomics reveals multiple metabolites influencing smoking-related DNA methylation. Epigenomics 10:379-393
de Mendoza, Veronica Barcelona; Huang, Yunfeng; Crusto, Cindy A et al. (2018) Perceived Racial Discrimination and DNA Methylation Among African American Women in the InterGEN Study. Biol Res Nurs 20:145-152
Wright, Michelle L; Ware, Erin B; Smith, Jennifer A et al. (2018) Joint Influence of SNPs and DNA Methylation on Lipids in African Americans From Hypertensive Sibships. Biol Res Nurs 20:161-167
Taylor, Jacquelyn Y; Barcelona de Mendoza, Veronica (2018) Improving -Omics-Based Research and Precision Health in Minority Populations: Recommendations for Nurse Scientists. J Nurs Scholarsh 50:11-19
Starkweather, Angela; Coleman, Bernice; Barcelona de Mendoza, Veronica et al. (2017) Policy brief: Improve coverage of newborn genetic screening to include the Recommended Uniform Screening Panel and newborn screening registry. Nurs Outlook 65:480-484
Wright, Michelle L; Huang, Yunfeng; Hui, Qin et al. (2017) Parenting stress and DNA methylation among African Americans in the InterGEN Study. J Clin Transl Sci 1:328-333
Barcelona de Mendoza, Veronica; Wright, Michelle L; Agaba, Comfort et al. (2017) A Systematic Review of DNA Methylation and Preterm Birth in African American Women. Biol Res Nurs 19:308-317
Taylor, Jacquelyn Y; Sun, Yan V; Barcelona de Mendoza, Veronica et al. (2017) The combined effects of genetic risk and perceived discrimination on blood pressure among African Americans in the Jackson Heart Study. Medicine (Baltimore) 96:e8369
Taylor, Jacquelyn Y; Gillespie, Gordon (2017) Diversity: A key aspect of 21st century faculty roles. Nurs Outlook 65:289
Taylor, Jacquelyn Y; Wright, Michelle L; Hickey, Kathleen T et al. (2017) Genome Sequencing Technologies and Nursing: What Are the Roles of Nurses and Nurse Scientists? Nurs Res 66:198-205

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