Mild Cognitive Impairment (MCI), especially amnestic type, is considered a symptomatic pre-Alzheimer's disease (AD) phase, and is prevalent in the aging population. Vision-based speed of processing (VSOP) cognitive training is one of the most widely applied behavioral interventions in community-dwelling older Americans free of AD, holding potential to slow cognitive decline. Its particular relevance to MCI is supported by converging evidence from our preliminary studies, including a recently completed pilot intervention study. However, we know little about the mechanisms underlying the benefits of VSOP training, limiting our ability to further exploit VSOP or other forms of cognitive training. I particular, we do not know if and how the effects of VSOP training on cognitive performance are mediated by neuroplasticity-related brain changes. Since recent evidence suggests that neuroplasticity is inducible throughout adult life, even in MCI, it is possible that VSOP training promotes neuroplasticity and slows neurodegeneration. In this early stage and new investigator application, we will focus on assessing whether and how VSOP training, relative to mental leisure activities (MLA), alters cognitive and neural functions in older adults with MCI, up to 6 months after training. The study will enroll and randomize 84 participants with amnestic MCI to VSOP training or MLA control groups. Three specific research aims are to (1) determine whether VSOP training improves processing speed and attention that are associated with changes of brain structural and functional connectivity; (2) test a novel neurophysiological pathway of VSOP training effect on brain structure and function; (3) examine the effect of VSOP training on untrained cognitive and functional domains and the role of neurophysiological changes underlying possible transfer effects. By examining multiple neural and novel physiological mechanisms linking a promising VSOP training intervention to improvements in cognitive performance, this application seeks to challenge and shift current research on cognitive training that merely examines training effects on cognitive outcomes. Discovery of neural, and physiological-related mechanisms in VSOP training will have important implications beyond this particular intervention. Findings from recent behavioral studies (e.g., cognitive intervention, physical exercise, nutrition, and bio-feedback intervention) suggest that for cognitive decline to be mitigated in individuals at risk for AD, it will be necessary for interventions to target the neural and peripheral physiological pathways that are susceptible to AD neuropathology. Confirmation of the study hypotheses could support immediate translation to clinical practices by demonstrating the efficacy, sustainability, and generalizability of cognitve training.

Public Health Relevance

This project seeks to identify neural changes that occur in adults with mild cognitive impairment (MCI) after engagement in computerized cognitive training. In addition, this project aims to identify physiological factors that may bolster effectsof the training on cognitive function. Individuals with MCI are at high risk for Alzheimer's disease (AD). Understanding how cognitive training protects cognitive function in MCI can contribute to development of effective interventions to slow progression to AD in individuals at risk, thereby reducing the significant morbidity and health care costs associated with AD.

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Research Project (R01)
Project #
1R01NR015452-01A1
Application #
8985335
Study Section
Behavioral Medicine, Interventions and Outcomes Study Section (BMIO)
Program Officer
Tully, Lois
Project Start
2015-09-05
Project End
2019-07-31
Budget Start
2015-09-05
Budget End
2016-07-31
Support Year
1
Fiscal Year
2015
Total Cost
$513,459
Indirect Cost
$175,368
Name
University of Rochester
Department
Type
Schools of Nursing
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
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Wang, Xixi; Ren, Ping; Mapstone, Mark et al. (2017) Identify a shared neural circuit linking multiple neuropsychiatric symptoms with Alzheimer's pathology. Brain Imaging Behav :
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Lin, Feng; Ren, Ping; Lo, Raymond Y et al. (2017) Insula and Inferior Frontal Gyrus' Activities Protect Memory Performance Against Alzheimer's Disease Pathology in Old Age. J Alzheimers Dis 55:669-678
Ren, Ping; Anthony, Mia; Chapman, Benjamin P et al. (2017) Amygdala functional connectivity is associated with locus of control in the context of cognitive aging. Neuropsychologia 99:199-206
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Ren, Ping; Lo, Raymond Y; Chapman, Benjamin P et al. (2016) Longitudinal Alteration of Intrinsic Brain Activity in the Striatum in Mild Cognitive Impairment. J Alzheimers Dis 54:69-78
Lin, Feng; Ren, Ping; Cotton, Kelly et al. (2016) Mental Fatigability and Heart Rate Variability in Mild Cognitive Impairment. Am J Geriatr Psychiatry 24:374-8
Lin, Feng; Heffner, Kathi L; Ren, Ping et al. (2016) Cognitive and Neural Effects of Vision-Based Speed-of-Processing Training in Older Adults with Amnestic Mild Cognitive Impairment: A Pilot Study. J Am Geriatr Soc 64:1293-8