A series of experiments are proposed in which the nature of human auditory development is investigated using the auditory evoked response (AER). These experiments are divided into four areas of inquiry: 1) Frequency specificity, 2) binaural interaction, 3) scalp topography, 4) fatique/adaptation. The outcome of the frequency specificity section will be a description of the development of auditory responsivity as a function of stimulus frequency. Continuous high pass noise, low pass noise, tones and forward masking paradigms will be used to determine the frequency specificity of the response. In addition, the assumptions underlying the applicability of masking techniques will be tested. The results of these measurements should also constitute frequency specific clinical norms, as a function of age. The outcome of the binaural interaction section will be a description of the time course of maturation of binaural interaction and its dependence upon stimulus frequence. Binaural interaction will also be described in a group of patients with central and peripheral auditory dysfunction. The scalp topography studies will result in a spatio-temporal map of the AER as a function of age and stimulus dependency. This information will assist in the selection of """"""""optimal"""""""" recording sites for clinical applications and the investigation of maturation of the auditory tract. The outcome of the adaptation/fatigue section will be description of the time course of maturation of these processes, and their interaction with stimulus variables. Such information should prove useful for the eventual development of noise-risk criteria for infants. As a group, these experiments will result in the creation of a multidimensional developmental space including the time course of maturation and stimulus dependency of each of its dimensions. Such a space not only provides a more complete description of auditory development, but may ultimately provide a more rational basis for the differential diagnosis of diseases affecting the auditory pathway.

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National Institute of Neurological Disorders and Stroke (NINDS)
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Hearing Research Study Section (HAR)
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University of Wisconsin Madison
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Laughlin, N K; Hartup, B K; Lasky, R E et al. (1999) The development of auditory event related potentials in the rhesus monkey (Macaca mulatta). Dev Psychobiol 34:37-56
Lasky, R E; Van Veen, B D; Maier, M M (1998) Nonlinear functional modeling of scalp recorded auditory evoked responses to maximum length sequences. Hear Res 120:133-42
Lasky, R E; Maier, M M; Hecox, K (1996) Auditory evoked brain stem responses to trains of stimuli in human adults. Ear Hear 17:544-51
Lasky, R E; Maier, M M; Snodgrass, E B et al. (1995) The effects of lead on otoacoustic emissions and auditory evoked potentials in monkeys. Neurotoxicol Teratol 17:633-44
Lasky, R E; Snodgrass, E B; Laughlin, N K et al. (1995) Distortion product otoacoustic emissions in Macaca mulatta and humans. Hear Res 89:35-51
Lasky, R E; Maier, M M; Hecox, K (1995) A comparison of binaural interactions using traditional and maximum length sequence evoked response paradigms. Ear Hear 16:354-60
Lasky, R E; Maier, M M; Snodgrass, E B et al. (1995) Auditory evoked brainstem and middle latency responses in Macaca mulatta and humans. Hear Res 89:212-25
Lasky, R E; Snodgrass, E; Hecox, K (1994) Distortion-product otoacoustic emission input/output functions as a function of frequency in human adults. J Am Acad Audiol 5:183-94
Lasky, R E (1993) The effect of forward masker duration, rise/fall time, and integrated pressure on auditory brain stem evoked responses in human newborns and adults. Ear Hear 14:95-103
Lasky, R E; Shi, Y; Hecox, K E (1993) Binaural maximum length sequence auditory-evoked brain-stem responses in human adults. J Acoust Soc Am 93:2077-87

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