The goal of this proposal is to determine the mechanisms that mediate the extensive reactivations of somatosensory cortex and the return of hand use after large lesions of cutaneous receptor afferents in the dorsal columns of the spinal cord. Our experiments will determine if new connections are formed in the post- lesion somatosensory system, if a promising treatment with an enzyme promotes useful new connections, and if reactivated neurons in somatosensory cortex have response properties to touch on the hand that would usefully guide tactile behavior.
The goal of our project is to better understand how individuals recover after extensive brain damage to the nervous system, and if certain treatments promote useful recoveries. We expect that our results, based on spinal cord injury, will apply broadly in understanding how the human nervous system recovers from injuries, and suggest clinical applications that would improve recoveries.
|Kaas, Jon H; Stepniewska, Iwona (2016) Evolution of posterior parietal cortex and parietal-frontal networks for specific actions in primates. J Comp Neurol 524:595-608|
|Qi, Hui-Xin; Wang, Feng; Liao, Chia-Chi et al. (2016) Spatiotemporal trajectories of reactivation of somatosensory cortex by direct and secondary pathways after dorsal column lesions in squirrel monkeys. Neuroimage 142:431-453|
|Liao, Chia-Chi; Reed, Jamie L; Kaas, Jon H et al. (2016) Intracortical connections are altered after long-standing deprivation of dorsal column inputs in the hand region of area 3b in squirrel monkeys. J Comp Neurol 524:1494-526|
|Sawyer, Eva K; Turner, Emily C; Kaas, Jon H (2016) Somatosensory brainstem, thalamus, and cortex of the California sea lion (Zalophus californianus). J Comp Neurol 524:1957-75|
|Qi, Hui-Xin; Reed, Jamie L; Franca, Joao G et al. (2016) Chronic recordings reveal tactile stimuli can suppress spontaneous activity of neurons in somatosensory cortex of awake and anesthetized primates. J Neurophysiol 115:2105-23|
|Liao, Chia-Chi; Qi, Hui-Xin; Reed, Jamie L et al. (2016) Congenital foot deformation alters the topographic organization in the primate somatosensory system. Brain Struct Funct 221:383-406|
|Liao, Chia-Chi; Reed, Jamie L; Qi, Hui-Xin (2016) Anatomical changes in the somatosensory system after large sensory loss predict strategies to promote functional recovery after spinal cord injury. Neural Regen Res 11:575-7|
|Reed, Jamie L; Liao, Chia-Chi; Qi, Hui-Xin et al. (2016) Plasticity and Recovery After Dorsal Column Spinal Cord Injury in Nonhuman Primates. J Exp Neurosci 10:11-21|
|Sawyer, Eva Kille; Liao, Chia-Chi; Qi, Hui-Xin et al. (2015) Subcortical barrelette-like and barreloid-like structures in the prosimian galago (Otolemur garnetti). Proc Natl Acad Sci U S A 112:7079-84|
|Cooke, Dylan F; Stepniewska, Iwona; Miller, Daniel J et al. (2015) Reversible Deactivation of Motor Cortex Reveals Functional Connectivity with Posterior Parietal Cortex in the Prosimian Galago (Otolemur garnettii). J Neurosci 35:14406-22|
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