The proposed experiments test the feasibility of using a particular class of electrical responses extracted from the brainwaves as a non-behavioral method for measuring hearing at the audiometric frequencies. The High Rates Response (HRR) with which the research is concerned is recorded through scalp electrodes when brief tonebursts are presented at high rates (15-60 per sec.) through an earphone; it is closely related to the so-called middle latency (8 to 80 msec.) auditory evoked potentials and has other names (e.g., 40 Hz ERP, MLR40, SMLR, etc.). Previous research has shown that the HRR predicts hearing thresholds less accurately in uncooperative or sleeping children than in quiet, wide-awake adults. We believe this lack of accuracy is due in part at least to current use of a single measure only--HRR amplitude at one stimulus rate--in the data analysis. Our research proposes to replace this with a single response statistic developed out of the multiple measures available after the Fourier transformation of the HRR, an approach that should theoretically improve both the accuracy of HRR measurements and the detectability of threshold responses. If successful, the research will first of all describe the design requirements for a practical electric response audiometer that will use the HRR to make threshold estimates quickly, accurately and automatically. Second, it will provide a new, efficient measure of brain responses to above-threshold stimuli that may find useful neurological applications in sleep studies and the diagnosis of abnormal brain states.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS017490-06
Application #
3397607
Study Section
Hearing Research Study Section (HAR)
Project Start
1981-07-01
Project End
1987-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
6
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Rady Children's Hospital-San Diego
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92123
Galambos, R (1995) EPIC X: past, present, future. Electroencephalogr Clin Neurophysiol Suppl 44:3-20
Galambos, R; Makeig, S (1992) Physiological studies of central masking in man. II: Tonepip SSRs and the masking level difference. J Acoust Soc Am 92:2691-7
Galambos, R; Makeig, S (1992) Physiological studies of central masking in man. I: The effects of noise on the 40-Hz steady-state response. J Acoust Soc Am 92:2683-90
Stapells, D R; Galambos, R; Costello, J A et al. (1988) Inconsistency of auditory middle latency and steady-state responses in infants. Electroencephalogr Clin Neurophysiol 71:289-95
Stapells, D R; Makeig, S; Galambos, R (1987) Auditory steady-state responses: threshold prediction using phase coherence. Electroencephalogr Clin Neurophysiol 67:260-70