The specific aims of this proposal are to develop the necessary chemistry to synthesize cis-enyne units with a cyclohexyl and piperidine unit. This chemistry will be extended to the synthesis of histrioni-cotoxin itself. The synthesis of batrachotoxin a potent toxin, is proposed. Both histrionicotoxin and batrachotoxin have evoked great interest through their interesting and useful biological action. The synthesis of histrionicotoxin will provide access to analogs that can be used to explore the mechanism of cholinergic response in those important neurophysiological tools. The synthesis of batrachotoxin, especially less toxic analogs will provide access to analogs that might be less toxic and useful for the treatment of muscular dystrophy.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS018125-03
Application #
3398206
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1981-07-01
Project End
1986-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Indiana University Bloomington
Department
Type
Schools of Arts and Sciences
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47402