In this application we combine the efforts of two long term studies investigating the neural mechanisms of tactile spatial perception. Dr. James Craig of Indiana University will not be renewing his grant but instead will be joining this project at Johns Hopkins University. The broad goals of this application are to understand how two-dimensional shape, texture and motion are represented in somatosensory cortex. Shape, texture and motion are important in all sensory systems. We will use a 400-probe stimulator that can produce a wide range of dynamic patterns to stimulate the finger pad. We will perform both psychophysical studies in humans and neurophysiological studies in non-human primates.
The first aim i s to understand how complex patterns are perceived and represented in somatosensory cortex. In these experiments we will investigate how spatial features such as lines and curves are combined both spatially and temporally to from complex spatial patterns.
The second aim i s to investigate how texture is represented in somatosensory cortex. In these experiments, we will use a wide range of spatial patterns that we used previously to study the peripheral mechanisms of texture perception to determine how texture is coded in cortex.
The third aim i s to investigate how motion is represented in cortex. In particular we will scan various spatial patterns across the finger pad at different directions and scanning velocities to determine how motion interacts with form and texture processing. The results from these studies will provide an understanding of the mechanisms underlying central neurological problems and will provide an understanding of the sensory feedback that is necessary for the control of prosthetic limbs. A third benefit is that these studies will aid in the development of cutaneous communication systems for the deaf and blind.

Public Health Relevance

The results from the proposed studies will aid our understanding of the effects of both peripheral and central neurological problems, and our interpretation of the results of neurological examinations, such as changes in light touch thresholds, spatial acuity, and directional sensitivity. To provide sensory feedback for the control of prosthetic limbs, it is important to understand how the hand normally processes touch information. In addition, the proposed measures of the perceptibility of tactile patterns will aid in the development of cutaneous communication systems for the blind, deaf, and deaf-blind.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS018787-30
Application #
8235055
Study Section
Special Emphasis Panel (ZRG1-IFCN-K (02))
Program Officer
Gnadt, James W
Project Start
1983-04-01
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2014-03-31
Support Year
30
Fiscal Year
2012
Total Cost
$622,167
Indirect Cost
$214,850
Name
Johns Hopkins University
Department
None
Type
Schools of Arts and Sciences
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Gwilliam, James C; Yoshioka, Takashi; Okamura, Allison M et al. (2014) Neural coding of passive lump detection in compliant artificial tissue. J Neurophysiol 112:1131-41
Gomez-Ramirez, Manuel; Trzcinski, Natalie K; Mihalas, Stefan et al. (2014) Temporal correlation mechanisms and their role in feature selection: a single-unit study in primate somatosensory cortex. PLoS Biol 12:e1002004
Tabot, Gregg A; Dammann, John F; Berg, Joshua A et al. (2013) Restoring the sense of touch with a prosthetic hand through a brain interface. Proc Natl Acad Sci U S A 110:18279-84
Dong, Yi; Mihalas, Stefan; Kim, Sung Soo et al. (2013) A simple model of mechanotransduction in primate glabrous skin. J Neurophysiol 109:1350-9
Berg, J A; Dammann 3rd, J F; Tenore, F V et al. (2013) Behavioral demonstration of a somatosensory neuroprosthesis. IEEE Trans Neural Syst Rehabil Eng 21:500-7
Kim, Sung Soo; Mihalas, Stefan; Russell, Alexander et al. (2011) Does afferent heterogeneity matter in conveying tactile feedback through peripheral nerve stimulation? IEEE Trans Neural Syst Rehabil Eng 19:514-20
Yoshioka, Takashi; Craig, James C; Beck, Graham C et al. (2011) Perceptual constancy of texture roughness in the tactile system. J Neurosci 31:17603-11
Pei, Yu-Cheng; Hsiao, Steven S; Craig, James C et al. (2011) Neural mechanisms of tactile motion integration in somatosensory cortex. Neuron 69:536-47
Kim, Sung Soo; Sripati, Arun P; Bensmaia, Sliman J (2010) Predicting the timing of spikes evoked by tactile stimulation of the hand. J Neurophysiol 104:1484-96
Pei, Yu-Cheng; Hsiao, Steven S; Craig, James C et al. (2010) Shape invariant coding of motion direction in somatosensory cortex. PLoS Biol 8:e1000305

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