The purpose of this proposal is to study the normal, experimentally-altered and regenerating cerebral microvasculature in vivo and cells derived from cerebral microvasculature in vitro in order to understand some of the specific factors that maintain its structural and functional integrity, lead to its orderly repair after injury, and to relate these studies to changes that occur in the """"""""blood-brain barrier"""""""" during micro-vascular injury and repair. Specifically, we propose to 1) define some of the cellular and molecular events which occur during regeneration; 2) document the relationships between endothelium and blood elements and cells, smooth muscle and astroglia; 3) determine the sequence of reestablishment of barrier properties after injury and 4) delineate some of the special biochemical properties of the endothelium. The approach will utilize a variety of techniques and will seek to correlate and interrelate in vivo and in vitro observations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS019279-03
Application #
3399288
Study Section
Pathology A Study Section (PTHA)
Project Start
1983-04-01
Project End
1986-06-30
Budget Start
1985-04-01
Budget End
1986-06-30
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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