Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS019522-14S1
Application #
2263612
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1982-09-01
Project End
1999-11-30
Budget Start
1994-12-01
Budget End
1995-11-30
Support Year
14
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Harvard University
Department
Biology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Kasheverov, Igor E; Chiara, David C; Zhmak, Maxim N et al. (2006) alpha-Conotoxin GI benzoylphenylalanine derivatives. (1)H-NMR structures and photoaffinity labeling of the Torpedo californica nicotinic acetylcholine receptor. FEBS J 273:1373-88
Andreeva, Iraida E; Nirthanan, Selvanayagam; Cohen, Jonathan B et al. (2006) Site specificity of agonist-induced opening and desensitization of the Torpedo californica nicotinic acetylcholine receptor. Biochemistry 45:195-204
Stewart, Deirdre S; Chiara, David C; Cohen, Jonathan B (2006) Mapping the structural requirements for nicotinic acetylcholine receptor activation by using tethered alkyltrimethylammonium agonists and antagonists. Biochemistry 45:10641-53
Hamouda, Ayman K; Chiara, David C; Sauls, Daniel et al. (2006) Cholesterol interacts with transmembrane alpha-helices M1, M3, and M4 of the Torpedo nicotinic acetylcholine receptor: photolabeling studies using [3H]Azicholesterol. Biochemistry 45:976-86
Chiara, David C; Trinidad, Jonathan C; Wang, Dong et al. (2003) Identification of amino acids in the nicotinic acetylcholine receptor agonist binding site and ion channel photolabeled by 4-[(3-trifluoromethyl)-3H-diazirin-3-yl]benzoylcholine, a novel photoaffinity antagonist. Biochemistry 42:271-83
Sullivan, Deirdre; Chiara, David C; Cohen, Jonathan B (2002) Mapping the agonist binding site of the nicotinic acetylcholine receptor by cysteine scanning mutagenesis: antagonist footprint and secondary structure prediction. Mol Pharmacol 61:463-72
Ramarao, M K; Bianchetta, M J; Lanken, J et al. (2001) Role of rapsyn tetratricopeptide repeat and coiled-coil domains in self-association and nicotinic acetylcholine receptor clustering. J Biol Chem 276:7475-83
Xie, Y; Cohen, J B (2001) Contributions of Torpedo nicotinic acetylcholine receptor gamma Trp-55 and delta Trp-57 to agonist and competitive antagonist function. J Biol Chem 276:2417-26
Gallagher, M J; Chiara, D C; Cohen, J B (2001) Interactions between 3-(Trifluoromethyl)-3-(m-[(125)I]iodophenyl)diazirine and tetracaine, phencyclidine, or histrionicotoxin in the Torpedo series nicotinic acetylcholine receptor ion channel. Mol Pharmacol 59:1514-22
Blanton, M P; Lala, A K; Cohen, J B (2001) Identification and characterization of membrane-associated polypeptides in Torpedo nicotinic acetylcholine receptor-rich membranes by hydrophobic photolabeling. Biochim Biophys Acta 1512:215-24

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