The long-term goals of this research project are to dissect the molecular and cellular biology of olfactory memory formation in Drosophila. A recent screen for new memory mutants with putative functions in the mushroom body neurons has uncovered several putative mutants, but one with a strong effect on performance immediately after training. Experiments are proposed to completely characterize the nature of the disrupted expression in different alleles of this gene, to reveal the spatial expression pattern of the gene within the olfactory nervous system, and to probe behaviorally whether the various alleles disrupt acquisition or memory stability. Genetic tests will reveal whether the mutant disrupts a molecule that is a member of well characterized signaling systems important for memory formation or whether this new gene represents the prototypic member of a parallel signaling system. Newly developed techniques to control transgene expression in time and in space will be used to address the issue of when and where the gene product is required for normal memory formation. Overall, the experiments will contribute to our understanding of the molecular biology of learning, an important process disrupted in many different diseases of the nervous system including Alzheimer's disease, schizophrenia, autism, and learning disabilities.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Project (R01)
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Study Section
Neurobiology of Learning and Memory Study Section (LAM)
Program Officer
Morris, Jill A
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Scripps Research Institute
La Jolla
United States
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Davis, Ronald L; Zhong, Yi (2017) The Biology of Forgetting-A Perspective. Neuron 95:490-503
Guven-Ozkan, Tugba; Busto, Germain U; Schutte, Soleil S et al. (2016) MiR-980 Is a Memory Suppressor MicroRNA that Regulates the Autism-Susceptibility Gene A2bp1. Cell Rep 14:1698-1709
Busto, Germain U; Guven-Ozkan, Tugba; Fulga, Tudor A et al. (2015) microRNAs That Promote or Inhibit Memory Formation in Drosophila melanogaster. Genetics 200:569-80
Davis, Ronald L (2015) SnapShot: Olfactory Classical Conditioning of Drosophila. Cell 163:524-524.e1
Berry, Jacob A; Cervantes-Sandoval, Isaac; Chakraborty, Molee et al. (2015) Sleep Facilitates Memory by Blocking Dopamine Neuron-Mediated Forgetting. Cell 161:1656-67
Tan, Ying; Yu, Dinghui; Busto, Germain U et al. (2013) Wnt signaling is required for long-term memory formation. Cell Rep 4:1082-9
Berry, Jacob A; Cervantes-Sandoval, Isaac; Nicholas, Eric P et al. (2012) Dopamine is required for learning and forgetting in Drosophila. Neuron 74:530-42
Akalal, David-Benjamin G; Yu, Dinghui; Davis, Ronald L (2011) The long-term memory trace formed in the Drosophila ?/? mushroom body neurons is abolished in long-term memory mutants. J Neurosci 31:5643-7
Davis, Ronald L (2011) Traces of Drosophila memory. Neuron 70:8-19
Buchanan, Monica E; Davis, Ronald L (2010) A distinct set of Drosophila brain neurons required for neurofibromatosis type 1-dependent learning and memory. J Neurosci 30:10135-43

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