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Basu, Dipannita; Tian, Yuxin; Bhandari, Jayant et al. (2013) Effects of the dopamine D2 allosteric modulator, PAOPA, on the expression of GRK2, arrestin-3, ERK1/2, and on receptor internalization. PLoS One 8:e70736
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Basu, Dipannita; Castellano, Jessica M; Thomas, Nancy et al. (2013) Cell-free protein synthesis and purification of human dopamine D2 receptor long isoform. Biotechnol Prog 29:601-8
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Tan, Mattea L; Basu, Dipannita; Kwiecien, Jacek M et al. (2013) Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia. Peptides 42:89-96
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Beyaert, Michael G R; Daya, Ritesh P; Dyck, Bailey A et al. (2013) PAOPA, a potent dopamine D2 receptor allosteric modulator, prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized preclinical animal model of schizophrenia. Eur Neuropsychopharmacol 23:253-62
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Bhagwanth, Swapna; Mishra, Ram K; Johnson, Rodney L (2013) Development of peptidomimetic ligands of Pro-Leu-Gly-NH(2) as allosteric modulators of the dopamine D(2) receptor. Beilstein J Org Chem 9:204-14
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Bhagwanth, Swapna; Mishra, Satyendra; Daya, Ritesh et al. (2012) Transformation of Pro-Leu-Gly-NH2 peptidomimetic positive allosteric modulators of the dopamine D2 receptor into negative modulators. ACS Chem Neurosci 3:274-84
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Dyck, Bailee; Guest, Kelly; Sookram, Christal et al. (2011) PAOPA, a potent analogue of Pro-Leu-glycinamide and allosteric modulator of the dopamine D2 receptor, prevents NMDA receptor antagonist (MK-801)-induced deficits in social interaction in the rat: implications for the treatment of negative symptoms in schi Schizophr Res 125:88-92
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Mann, Amandeep; Verma, Vaneeta; Basu, Dipannita et al. (2010) Specific binding of photoaffinity-labeling peptidomimetics of Pro-Leu-Gly-NH2 to the dopamine D2L receptor: evidence for the allosteric modulation of the dopamine receptor. Eur J Pharmacol 641:96-101
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Wood, Richard L; Young-Dixon, Brendan J; Roy, Abhrajeet et al. (2010) Evaluation of Density Functionals, SCC-DFTB, Neglect of Diatomic Differential Overlap (NDDO) Models and Molecular Mechanics Methods for Prolyl-Leucyl-Glycinamide (PLG) and Structural Derivatives. Theochem 944:76-82
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Raghavan, Bhooma; Skoblenick, Kevin J; Bhagwanth, Swapna et al. (2009) Allosteric modulation of the dopamine D2 receptor by Pro-Leu-Gly-NH2 peptidomimetics constrained in either a polyproline II helix or a type II beta-turn conformation. J Med Chem 52:2043-51
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Showing the most recent 10 out of 45 publications
