Abstract

The proposed research is an extension of ongoing investigations of the role of intercellular communication in the regulation of neuronal growth and development. These studies will examine the biochemical consequences of neurotransmitter interactions, and the role of such interactions in neuronal phenotypic expression. The rat sympathetic superior cervival ganglion (SCG) in vitro will be used to study the influences of peptide transmitters on sympathetic phenotypic expression, and conversely to examine mechanisms regulating expressions of peptidergic triats by autonomic neurons. More specifically, we plan to: a) Characterize the effects of the peptide neurotransmitters, substance P (SP), somatostatin (SS), and vasoactive intestinal polypeptide (VIP) on the development of noradrenergic traits in sympathetic neurons; b) Define factors regulating the expression of the SP, SS, and VIP phenotypes by sympathetic neurons; c) Examine the role of intercellular interactions in peptidergic expression by sympathetic neurons. In a broader sense, these studies seek to define the molecular basis of neurotransmitter mutability and synaptic plasticity. It is hoped that such studies may indicate biochemical loci where therapeutic intervention in disease processes may lead to a return to normal neuronal function.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS020778-03
Application #
3401353
Study Section
Neurology B Subcommittee 1 (NEUB)
Project Start
1984-04-01
Project End
1987-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Chen, Jessie; Van Gulden, Stephanie; McGuire, Tammy L et al. (2018) BMP-Responsive Protease HtrA1 Is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury Response. J Neurosci 38:3840-3857
Tysseling, Vicki M; Mithal, Divakar S; Sahni, Vibhu et al. (2017) Erratum to: SDF1 in the dorsal corticospinal tract promotes CXCR4+ cell migration after spinal cord injury. J Neuroinflammation 14:35
Brooker, S M; Gobeske, K T; Chen, J et al. (2017) Hippocampal bone morphogenetic protein signaling mediates behavioral effects of antidepressant treatment. Mol Psychiatry 22:910-919
Brooker, Sarah M; Bond, Allison M; Peng, Chian-Yu et al. (2016) ?1-integrin restricts astrocytic differentiation of adult hippocampal neural stem cells. Glia 64:1235-51
Meyers, Emily A; Gobeske, Kevin T; Bond, Allison M et al. (2016) Increased bone morphogenetic protein signaling contributes to age-related declines in neurogenesis and cognition. Neurobiol Aging 38:164-175
Kang, Wonmo; McNaughton, Rebecca L; Espinosa, Horacio D (2016) Micro- and Nanoscale Technologies for Delivery into Adherent Cells. Trends Biotechnol 34:665-678
Apkarian, A Vania; Mutso, Amelia A; Centeno, Maria V et al. (2016) Role of adult hippocampal neurogenesis in persistent pain. Pain 157:418-28
Venkatesan, Charu; Birch, Derin; Peng, Chian-Yu et al. (2015) Astrocytic ?1-integrin affects cellular composition of murine blood brain barrier in the cerebral cortex. Int J Dev Neurosci 44:48-54
North, Hilary A; Pan, Liuliu; McGuire, Tammy L et al. (2015) ?1-Integrin alters ependymal stem cell BMP receptor localization and attenuates astrogliosis after spinal cord injury. J Neurosci 35:3725-33
Duan, Lishu; Peng, Chian-Yu; Pan, Liuliu et al. (2015) Human pluripotent stem cell-derived radial glia recapitulate developmental events and provide real-time access to cortical neurons and astrocytes. Stem Cells Transl Med 4:437-47

Showing the most recent 10 out of 131 publications