Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS021954-08S1
Application #
2264323
Study Section
Experimental Virology Study Section (EVR)
Project Start
1985-07-01
Project End
1996-01-31
Budget Start
1994-02-01
Budget End
1995-01-31
Support Year
8
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Navas-Martin, Sonia; Brom, Maarten; Chua, Ming-Ming et al. (2007) Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 3'one-third of the genome. J Virol 81:1022-6
Weiss, Susan R; Navas-Martin, Sonia (2005) Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev 69:635-64
Navas-Martin, Sonia; Hingley, Susan T; Weiss, Susan R (2005) Murine coronavirus evolution in vivo: functional compensation of a detrimental amino acid substitution in the receptor binding domain of the spike glycoprotein. J Virol 79:7629-40
Navas-Martin, Sonia R; Weiss, Susan (2004) Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development. J Neurovirol 10:75-85
Tsai, Jean C; de Groot, Linda; Pinon, Josefina D et al. (2003) Amino acid substitutions within the heptad repeat domain 1 of murine coronavirus spike protein restrict viral antigen spread in the central nervous system. Virology 312:369-80
Zelus, Bruce D; Schickli, Jeanne H; Blau, Dianna M et al. (2003) Conformational changes in the spike glycoprotein of murine coronavirus are induced at 37 degrees C either by soluble murine CEACAM1 receptors or by pH 8. J Virol 77:830-40
Tsai, Jean C; Zelus, Bruce D; Holmes, Kathryn V et al. (2003) The N-terminal domain of the murine coronavirus spike glycoprotein determines the CEACAM1 receptor specificity of the virus strain. J Virol 77:841-50
Navas-Martin, Sonia; Weiss, Susan R (2003) SARS: lessons learned from other coronaviruses. Viral Immunol 16:461-74
Navas, Sonia; Weiss, Susan R (2003) Murine coronavirus-induced hepatitis: JHM genetic background eliminates A59 spike-determined hepatotropism. J Virol 77:4972-8
Das Sarma, Jayasri; Scheen, Esther; Seo, Su-Hun et al. (2002) Enhanced green fluorescent protein expression may be used to monitor murine coronavirus spread in vitro and in the mouse central nervous system. J Neurovirol 8:381-91

Showing the most recent 10 out of 55 publications