Midline section of the corpus callosum is carried out in an effort to control multifocal epilepsy. Recently there has been renewed interest in this surgical approach, and, as a consequence, many more patients are becoming available for long-term neuropsychological study. In addition, it has recently been demonstrated that NMR Imaging allows for the verification of the extent of surgical section. Both of these developments allow for unique opportunities to examine several issues. Specifically, we propose to study (1) the neurobehavioral consequences of callosal section with particular emphasis on changes in perceptual, motor, memory, and language functions; 2) the specific function of callosal pathways both intentionally and inadvertently spared; 3) the relatively common failure of the disconnected right hemispheres to perform cognitive and perceptual tasks; and 4) the phonologic, semantic and syntactic capacity of patients with right hemisphere language. Taken together, these studies will provide insight into cortical and subcortical processes involved in normal human cognition.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS022626-04
Application #
3405289
Study Section
Neurology A Study Section (NEUA)
Project Start
1988-07-01
Project End
1992-06-30
Budget Start
1988-07-01
Budget End
1989-06-30
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Gazzaniga, M S (1998) Brain and conscious experience. Adv Neurol 77:181-92;discussion 192-3
Baynes, K; Tramo, M J; Reeves, A G et al. (1997) Isolation of a right hemisphere cognitive system in a patient with anarchic (alien) hand sign. Neuropsychologia 35:1159-73
Fendrich, R; Wessinger, C M; Gazzaniga, M S (1996) Nasotemporal overlap at the retinal vertical meridian: investigations with a callosotomy patient. Neuropsychologia 34:637-46
Gazzaniga, M S; Eliassen, J C; Nisenson, L et al. (1996) Collaboration between the hemispheres of a callosotomy patient. Emerging right hemisphere speech and the left hemisphere interpreter. Brain 119 ( Pt 4):1255-62
Reuter-Lorenz, P A; Nozawa, G; Gazzaniga, M S et al. (1995) Fate of neglected targets: a chronometric analysis of redundant target effects in the bisected brain. J Exp Psychol Hum Percept Perform 21:211-30
Gazzaniga, M S (1995) On neural circuits and cognition. Neural Comput 7:1-12
Gazzaniga, M S (1995) Principles of human brain organization derived from split-brain studies. Neuron 14:217-28
Seymour, S E; Reuter-Lorenz, P A; Gazzaniga, M S (1994) The disconnection syndrome. Basic findings reaffirmed. Brain 117 ( Pt 1):105-15
Gazzaniga, M S (1993) Brain mechanisms and conscious experience. Ciba Found Symp 174:247-57;discussion 257-62
Baynes, K; Tramo, M J; Gazzaniga, M S (1992) Reading with a limited lexicon in the right hemisphere of a callosotomy patient. Neuropsychologia 30:187-200

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