Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS023691-01
Application #
3407469
Study Section
Neurology B Subcommittee 1 (NEUB)
Project Start
1985-09-01
Project End
1989-11-30
Budget Start
1985-09-01
Budget End
1985-11-30
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Yoshikawa, H; Lambert, E H; Walser-Kuntz, D R et al. (1997) A 17-Mer self-peptide of acetylcholine receptor binds to B cell MHC class II, activates helper T cells, and stimulates autoantibody production and electrophysiologic signs of myasthenia gravis. J Immunol 159:1570-7
Sano, M; Lambert, E H; McCormick, D J et al. (1992) Muscle acetylcholine receptors complexed with autologous IgG reflect seropositivity but not necessarily in vivo binding. Neurology 42:218-22
Lennon, V A; Lambert, E H; Leiby, K R et al. (1991) Recombinant human acetylcholine receptor alpha-subunit induces chronic experimental autoimmune myasthenia gravis. J Immunol 146:2245-8
Lennon, V A; Lambert, E H (1989) Autoantibodies bind solubilized calcium channel-omega-conotoxin complexes from small cell lung carcinoma: a diagnostic aid for Lambert-Eaton myasthenic syndrome. Mayo Clin Proc 64:1498-504
De Aizpurua, H J; Griesmann, G E; Lambert, E H et al. (1988) Voltage-dependent Ca2+ channels in small cell carcinomas are blocked by autoantibodies from patients with Lambert-Eaton myasthenic syndrome. Ann N Y Acad Sci 540:369-71
De Aizpurua, H J; Lambert, E H; Griesmann, G E et al. (1988) Antagonism of voltage-gated calcium channels in small cell carcinomas of patients with and without Lambert-Eaton myasthenic syndrome by autoantibodies omega-conotoxin and adenosine. Cancer Res 48:4719-24
Lambert, E H; Lennon, V A (1988) Selected IgG rapidly induces Lambert-Eaton myasthenic syndrome in mice: complement independence and EMG abnormalities. Muscle Nerve 11:1133-45
Lennon, V A; Huang, Z X; McCormick, D J et al. (1988) Synthetic peptide of human acetylcholine receptor alpha-subunit sequence 125-147 (methionine 144), a more potent autoantigen than its norleucine 144 analog. Ann N Y Acad Sci 540:516-9
McCormick, D J; Griesmann, G E; Huang, Z X et al. (1987) Myasthenogenicity of human acetylcholine receptor synthetic alpha-subunit peptide 125-147 does not require intramolecular disulfide cyclization. J Immunol 139:2615-9
Lennon, V A; Griesmann, G A; McCormick, D J et al. (1987) Definition of myasthenogenic sites of the human acetylcholine receptor using synthetic peptides. Ann N Y Acad Sci 505:439-50