Neurological Disease and the Electron Transport Chain

Parker, William B.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Project (R01)
• Project #: 7R01NS025382-06
• Application #: 2265548
• Study Section: Physical Biochemistry Study Section (PB)
• Project Start: 1988-02-01
• Project End: 1994-12-31
• Budget Start: 1993-09-01
• Budget End: 1994-12-31
• Support Year: 6
• Fiscal Year: 1992

Institution

• Name: University of Virginia
• Department: Neurology
• Type: Schools of Medicine
• DUNS #: 001910777
• City: Charlottesville
• State: VA
• Country: United States
• Zip Code: 22904

Publications

Swerdlow, R H; Parks, J K; Miller, S W et al. (1996) Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol 40:663-71

Howell, N; Kubacka, I; Smith, R et al. (1996) Association of the mitochondrial 8344 MERRF mutation with maternally inherited spinocerebellar degeneration and Leigh disease. Neurology 46:219-22

Parker Jr, W D; Parks, J; Filley, C M et al. (1994) Electron transport chain defects in Alzheimer's disease brain. Neurology 44:1090-6

Burkhardt, C; Kelly, J P; Lim, Y H et al. (1993) Neuroleptic medications inhibit complex I of the electron transport chain. Ann Neurol 33:512-7

Bennett, M C; Diamond, D M; Stryker, S L et al. (1992) Cytochrome oxidase inhibition: a novel animal model of Alzheimer's disease. J Geriatr Psychiatry Neurol 5:93-101

Parker Jr, W D (1991) Preclinical detection of Parkinson's disease: biochemical approaches. Neurology 41:34-6;discussion 36-7

Parker Jr, W D (1991) Cytochrome oxidase deficiency in Alzheimer's disease. Ann N Y Acad Sci 640:59-64

Parker Jr, W D; Boyson, S J; Luder, A S et al. (1990) Evidence for a defect in NADH: ubiquinone oxidoreductase (complex I) in Huntington's disease. Neurology 40:1231-4

Parker Jr, W D; Filley, C M; Parks, J K (1990) Cytochrome oxidase deficiency in Alzheimer's disease. Neurology 40:1302-3

Parker Jr, W D; Boyson, S J; Parks, J K (1989) Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann Neurol 26:719-23