Abstract

The experiments in this proposal are designed to continue investigations into neuronal processes controlling dopamine modulation of responses mediated by activation of glutamate and GABA receptors in the striatum. The first two aims are a direct continuation of studies begun in the presently funded proposal and will examine the hypothesis that the direction of DA modulation of responses mediated by activation of glutamate receptors is a function of the subtype of glutamate receptor activated and the subtype of DA receptor activated.
The third aim i s new and will examine the hypothesis that the direction of DA modulation of responses mediated by activation of GABA-A receptors is a function of the DA receptor subtype activated, its site of location on pre- and/or postsynaptic elements and the type of neuron.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS033538-04
Application #
2859400
Study Section
Special Emphasis Panel (ZRG1-IFCN-5 (01))
Program Officer
Murphy, Diane
Project Start
1996-06-01
Project End
2004-05-31
Budget Start
1999-06-01
Budget End
2000-05-31
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Psychiatry
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Holley, Sandra M; Wang, Elizabeth A; Cepeda, Carlos et al. (2013) Frontal cortical synaptic communication is abnormal in Disc1 genetic mouse models of schizophrenia. Schizophr Res 146:264-72
Ma, Yao-Ying; Cepeda, Carlos; Chatta, Payush et al. (2012) Regional and cell-type-specific effects of DAMGO on striatal D1 and D2 dopamine receptor-expressing medium-sized spiny neurons. ASN Neuro 4:
Cepeda, Carlos; Levine, Michael S (2012) Dopamine-NMDA receptor interactions: twenty years later. Dev Neurosci 34:2-4
Lam, Hoa A; Wu, Nanping; Cely, Ingrid et al. (2011) Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human ?-synuclein. J Neurosci Res 89:1091-102
Andre, Veronique M; Cepeda, Carlos; Cummings, Damian M et al. (2010) Dopamine modulation of excitatory currents in the striatum is dictated by the expression of D1 or D2 receptors and modified by endocannabinoids. Eur J Neurosci 31:14-28
Wu, Nanping; Joshi, Prasad R; Cepeda, Carlos et al. (2010) Alpha-synuclein overexpression in mice alters synaptic communication in the corticostriatal pathway. J Neurosci Res 88:1764-76
Cummings, Damian M; Yamazaki, Irene; Cepeda, Carlos et al. (2008) Neuronal coupling via connexin36 contributes to spontaneous synaptic currents of striatal medium-sized spiny neurons. J Neurosci Res 86:2147-58
Cepeda, Carlos; Andre, Veronique M; Yamazaki, Irene et al. (2008) Differential electrophysiological properties of dopamine D1 and D2 receptor-containing striatal medium-sized spiny neurons. Eur J Neurosci 27:671-82
Bamford, Nigel S; Zhang, Hui; Joyce, John A et al. (2008) Repeated exposure to methamphetamine causes long-lasting presynaptic corticostriatal depression that is renormalized with drug readministration. Neuron 58:89-103
Hernandez-Echeagaray, Elizabeth; Cepeda, Carlos; Ariano, Marjorie A et al. (2007) Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype. Neurochem Res 32:229-40

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