The frontal cortex arguably houses the most important set of integrators of cognition, emotion and motor control in the mammalian brain. Therefore, understanding the genetic mechanisms that control development of the prefrontal and motor cortex have clear ramifications for understanding neuropsychiatric disorders. I hypothesize that one can gain fundamental insights into this subject through the analysis of how Fgf8 signaling regulates development of the telencephalon. Fgf8 signaling is now firmly established as a central mechanism that controls molecular regionalization and morphogenesis of the rostral telencephalon, including the frontal neocortex. In this grant application I describe experiments aimed at testing the hypothesis that analysis of mice bearing mutations in Fgf agonists (Fgf8, 15 and 17), FGF antagonists (Sproutyl and 2) and transcription factors that are regulated by Fgf8 (COUPTF1 and Emx2) will elucidate mechanisms that regulate the size, nature and function of the frontal cortex.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS034661-13
Application #
7760968
Study Section
Neurogenesis and Cell Fate Study Section (NCF)
Program Officer
Riddle, Robert D
Project Start
1996-09-01
Project End
2011-01-31
Budget Start
2010-02-01
Budget End
2011-01-31
Support Year
13
Fiscal Year
2010
Total Cost
$424,153
Indirect Cost
Name
University of California San Francisco
Department
Psychiatry
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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