Neurotrophins play an essential role in the production, survival and maintenance of neurons in peripheral nerve ganglia. However, little is known about the impact of neurotrophins on the actual innervation of the skin where the full range of neuronal phenotypes and target selection are expressed. The wide variety of organized sensory and autonomic endings in the mystacial pad will be used in an assay to test several hypotheses about neurotrophin signaling mechanisms. These hypotheses are based on several important and surprising observations about the impact of null mutations and overexpression of neurotrophins in skin. The PI now plans to determine neurotrophin receptor expressions for each of the developing sets of innervation to the normal mouse and rat mystacial pad. Neurotrophin receptor expression will also be studied in mice with null mutations for neurotrophins and their receptors and in transgenic mice overexpressing neurotrophins in the skin. The impact of NGF and NT-3 overexpression on sensory and sympathetic endings will be assessed. Finally, the role of p75 in mediating the dramatic suppression of terminal arborization mediated by BDNF will be assessed. These studies should enhance our understanding of the role of neurotrophins and their receptors in regulating the development of specific types cutaneous innervation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS034692-02
Application #
2892023
Study Section
Neurology B Subcommittee 2 (NEUB)
Program Officer
Nichols, Paul L
Project Start
1998-04-01
Project End
2002-03-31
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Albany Medical College
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Albany
State
NY
Country
United States
Zip Code
12208
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