Over the last decade, our group has been pursuing a line of research with the overarching goal of discovering strategies used by the central nervous system (CMS) in motor tasks that require the coordination of redundant sets of elements. In this proposal, we plan to focus on the issue of timing in motor synergies. We view this issue as central for progress in understanding both basic mechanisms of and impairments in motor coordination. The development of the uncontrolled manifold hypothesis has allowed to quantify synergies and to monitor their changes both in the process of action and with practice. Based on recent experiments and pilot studies, a set of specific hypotheses have been formulated related to: (1) Ability of the central nervous system (CMS) to quickly create or modify a task-specific synergy in response to an imperative stimulus or to a mechanical perturbation of one of the elements; (2) Two stages in the effects of practice on muscle synergies participating in the stabilization of the vertical posture; (3) The role of timing errors in outputs of individual elements in the structure of motor variability of a multi- element system such as the human hand;and (4) Existence of timing synergies, i.e. task-specific covariations in the timing of changes in elemental variables that keep the timing of an important performance variable constant. Seven experiments will be performed to address eight specific hypotheses. The experiments will involve multi-finger force and moment production during pressing and grasping, as well as postural tasks. Two models will be developed. One of these will generalize to multi-element systems an earlier model of single- joint motor variability. The other model will explore a neurophysiologically plausible network functioning on a central back-coupling principle, that can replicate certain salient features of motor synergies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS035032-14
Application #
7759148
Study Section
Special Emphasis Panel (ZRG1-BBBP-H (04))
Program Officer
Chen, Daofen
Project Start
1997-02-01
Project End
2011-01-31
Budget Start
2010-02-01
Budget End
2011-01-31
Support Year
14
Fiscal Year
2010
Total Cost
$271,974
Indirect Cost
Name
Pennsylvania State University
Department
Miscellaneous
Type
Schools of Allied Health Profes
DUNS #
003403953
City
University Park
State
PA
Country
United States
Zip Code
16802
Solnik, Stanislaw; Qiao, Mu; Latash, Mark L (2017) Effects of visual feedback and memory on unintentional drifts in performance during finger-pressing tasks. Exp Brain Res 235:1149-1162
Reschechtko, Sasha; Zatsiorsky, Vladimir M; Latash, Mark L (2017) The synergic control of multi-finger force production: stability of explicit and implicit task components. Exp Brain Res 235:1-14
Piscitelli, Daniele; Falaki, Ali; Solnik, Stanislaw et al. (2017) Anticipatory postural adjustments and anticipatory synergy adjustments: preparing to a postural perturbation with predictable and unpredictable direction. Exp Brain Res 235:713-730
Falaki, Ali; Huang, Xuemei; Lewis, Mechelle M et al. (2017) Dopaminergic modulation of multi-muscle synergies in postural tasks performed by patients with Parkinson's disease. J Electromyogr Kinesiol 33:20-26
Falaki, Ali; Huang, Xuemei; Lewis, Mechelle M et al. (2017) Motor equivalence and structure of variance: multi-muscle postural synergies in Parkinson's disease. Exp Brain Res 235:2243-2258
Parsa, Behnoosh; Zatsiorsky, Vladimir M; Latash, Mark L (2017) Optimality and stability of intentional and unintentional actions: II. Motor equivalence and structure of variance. Exp Brain Res 235:457-470
Reschechtko, Sasha; Hasanbarani, Fariba; Akulin, Vladimir M et al. (2017) Unintentional force changes in cyclical tasks performed by an abundant system: Empirical observations and a dynamical model. Neuroscience 350:94-109
Latash, Mark L (2017) Stability of Kinesthetic Perception in Efferent-Afferent Spaces: The Concept of Iso-perceptual Manifold. Neuroscience 372:97-113
Rasouli, Omid; Solnik, Stanis?aw; Furmanek, Mariusz P et al. (2017) Unintentional drifts during quiet stance and voluntary body sway. Exp Brain Res 235:2301-2316
Parsa, Behnoosh; Terekhov, Alexander; Zatsiorsky, Vladimir M et al. (2017) Optimality and stability of intentional and unintentional actions: I. Origins of drifts in performance. Exp Brain Res 235:481-496

Showing the most recent 10 out of 261 publications