During the previous period of support, we have introduced, explored, and developed an approach to motor synergies based on the principle of abundance and using the computational tools of the uncontrolled manifold hypothesis. Now we suggest focusing on three major goals. First, we plan to analyze interaction of synergies at different levels of a control hierarchy. Second, we will explore the purposes and benefits of using synergic control to move closer to application of these ideas to everyday movements and disordered movements. Third, we will explore differences between the synergies involved in two basic classes of actions, discrete and cyclic. The planned experiments will address the following main questions: What is the purpose of synergies? How do synergies at different levels of a control hierarchy interact with each other? Are there qualitative differences in the synergic mechanisms during cyclic and discrete actions? We will perform eight experiments using several of the novel experimental devices constructed in our group, such as the "inverse piano", the "collapsing cup", and the "handle with spring-loaded sensors". Each experiment will test 2-4 specific hypotheses. The long-term goal of this research is to develop a coherent theoretical view on and advance the current understanding of how natural multieffector human movements are controlled and coordinated. Developing such a view would have a profound impact on the practice of preventing and treating motor disorders. These studies will also contribute to developing a toolbox to study motor synergies during both unimpaired and disordered movements.

Public Health Relevance

The overarching goal of the proposed research is to advance the current understanding of the organization, purposes, and benefits of synergic control of movements. We plan to move closer to application of these ideas to everyday motor tasks and disordered movements. At the same time, we are developing a toolbox to study motor synergies;such a toolbox may be applied to both unimpaired and disordered movements.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS035032-17
Application #
8416969
Study Section
Special Emphasis Panel (ZRG1-MOSS-D (02))
Program Officer
Chen, Daofen
Project Start
1997-02-01
Project End
2016-01-31
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
17
Fiscal Year
2013
Total Cost
$300,436
Indirect Cost
$81,039
Name
Pennsylvania State University
Department
Miscellaneous
Type
Schools of Allied Health Profes
DUNS #
003403953
City
University Park
State
PA
Country
United States
Zip Code
16802
Reschechtko, Sasha; Zatsiorsky, Vladimir M; Latash, Mark L (2016) The synergic control of multi-finger force production: stability of explicit and implicit task components. Exp Brain Res :
Falaki, Ali; Huang, Xuemei; Lewis, Mechelle M et al. (2016) Impaired synergic control of posture in Parkinson's patients without postural instability. Gait Posture 44:209-15
Jo, H J; Maenza, C; Good, D C et al. (2016) Effects of unilateral stroke on multi-finger synergies and their feed-forward adjustments. Neuroscience 319:194-205
Jo, Hang Jin; Ambike, Satyajit; Lewis, Mechelle M et al. (2016) Finger force changes in the absence of visual feedback in patients with Parkinson's disease. Clin Neurophysiol 127:684-92
Ambike, Satyajit; Mattos, Daniela; Zatsiorsky, Vladimir M et al. (2016) Unsteady steady-states: central causes of unintentional force drift. Exp Brain Res 234:3597-3611
Latash, Mark L (2016) Towards physics of neural processes and behavior. Neurosci Biobehav Rev 69:136-46
Ambike, S; Mattos, D; Zatsiorsky, V M et al. (2016) Synergies in the space of control variables within the equilibrium-point hypothesis. Neuroscience 315:150-61
Parsa, Behnoosh; Ambike, Satyajit; Terekhov, Alexander et al. (2016) Analytical Inverse Optimization in Two-Hand Prehensile Tasks. J Mot Behav 48:424-34
Solnik, Stanislaw; Reschechtko, Sasha; Wu, Yen-Hsun et al. (2016) Interpersonal synergies: static prehension tasks performed by two actors. Exp Brain Res 234:2267-82
Parsa, Behnoosh; Zatsiorsky, Vladimir M; Latash, Mark L (2016) Optimality and stability of intentional and unintentional actions: II. Motor equivalence and structure of variance. Exp Brain Res :

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