Abstract

This proposal aims to determine the kinetics of in vivo cerebral glucose uptake and utilization in health humans and to compare cerebral glucose concentration in IDDM and nondiabetic subjects. All experiments will be performed under strictly controlled metabolic conditions using high field (4 Tesla) magnetic resonance spectroscopy to measure the intracerebral glucose concentrations which is then used to calculate the rates of cerebral glucose transport and metabolism.
The specific aims of the project are to determine: 1) the kinetics of glucose-mediated cerebral glucose uptake in healthy humans and to compared kinetics in the occipital cortex and the periventricular white matter; 2 whether the intracerebral glucose concentrations are comparable in normal controls Qld. in subjects with IDDM when measured at the same plasma concentrations of glucose and insulin. The completion of these studies should allow one to define the kinetics of in vivo cerebral glucose uptake and metabolism in humans for two regions of the brain and the effects of antecedent chronic hyperglycemia on cerebral glucose uptake and metabolism in subjects with diabetes. It is hoped that the application of such knowledge to the care of diabetic patients, should decrease their risk of cerebral dysfunction and of hypoglycemia unawareness.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS035192-03
Application #
2883702
Study Section
Metabolism Study Section (MET)
Program Officer
Jacobs, Tom P
Project Start
1997-05-26
Project End
2000-03-31
Budget Start
1999-03-01
Budget End
2000-03-31
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Seaquist, Elizabeth R; Moheet, Amir; Kumar, Anjali et al. (2017) Hypothalamic Glucose Transport in Humans During Experimentally Induced Hypoglycemia-Associated Autonomic Failure. J Clin Endocrinol Metab 102:3571-3580
Joers, James M; Deelchand, Dinesh K; Kumar, Anjali et al. (2017) Measurement of Hypothalamic Glucose Under Euglycemia and Hyperglycemia by MRI at 3T. J Magn Reson Imaging 45:681-691
Öz, Gülin; DiNuzzo, Mauro; Kumar, Anjali et al. (2015) Revisiting Glycogen Content in the Human Brain. Neurochem Res 40:2473-81
Adanyeguh, Isaac M; Henry, Pierre-Gilles; Nguyen, Tra M et al. (2015) In vivo neurometabolic profiling in patients with spinocerebellar ataxia types 1, 2, 3, and 7. Mov Disord 30:662-70
Seaquist, Elizabeth R (2015) The Impact of Diabetes on Cerebral Structure and Function. Psychosom Med 77:616-21
Bedna?ík, Petr; Moheet, Amir; Deelchand, Dinesh K et al. (2015) Feasibility and reproducibility of neurochemical profile quantification in the human hippocampus at 3?T. NMR Biomed 28:685-93
Öz, Gülin (2015) MR Spectroscopy: A Longitudinal Biomarker for Substantia Nigra Pathology in Parkinson's Disease? Mov Disord 30:1304-5
Khowaja, Ameer; Choi, In-Young; Seaquist, Elizabeth R et al. (2015) In vivo Magnetic Resonance Spectroscopy of cerebral glycogen metabolism in animals and humans. Metab Brain Dis 30:255-61
Terpstra, Melissa; Moheet, Amir; Kumar, Anjali et al. (2014) Changes in human brain glutamate concentration during hypoglycemia: insights into cerebral adaptations in hypoglycemia-associated autonomic failure in type 1 diabetes. J Cereb Blood Flow Metab 34:876-82
Moheet, A; Emir, U E; Terpstra, M et al. (2014) Initial experience with seven tesla magnetic resonance spectroscopy of hypothalamic GABA during hyperinsulinemic euglycemia and hypoglycemia in healthy humans. Magn Reson Med 71:12-8

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