Previous studies have suggested that mossy cells are lost from the neuronal circuit of the dentate gyrus after various epiletogenic insults, and has given rise to the widely accepted, although often questioned, so called """"""""dormant basket cell"""""""" hypothesis of epileptogenesis. In the previous award made to Dr. Soltesz he has set out to comprehensive challenge and explore at a cellular and synaptic level each element of the dentate-gyrus-hippocampal circuit to explore what elements are directly and indirectly impacted in a model of fluid percussion head trauma. This competitive renewal turns the focus of the study to the principal hilar neuron the """"""""mossy cell"""""""" and proposes a rather straightforward set of experiments to disprove the """"""""dormant basket cell hypothesis"""""""" and demonstrate that instead of being lost in models of epileptogenesis, significant numbers of mossy cells persist following percussive head trauma and contribute to an increased hyperexcitability by entering into a increased recurrent excitation of dentate gyrus granule cells which in turn feedback to both inhibitory interneurons and hilar mossy cells to increase hippocampal excitability and the resultant epileptogenic activity.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-BDCN-3 (02))
Program Officer
Fureman, Brandy E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Irvine
Anatomy/Cell Biology
Schools of Medicine
United States
Zip Code
Neubrandt, Máté; Oláh, Viktor János; Brunner, János et al. (2018) Single Bursts of Individual Granule Cells Functionally Rearrange Feedforward Inhibition. J Neurosci 38:1711-1724
Neumann, Adam R; Raedt, Robrecht; Steenland, Hendrik W et al. (2017) Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy. Brain 140:2355-2369
Bui, Anh D; Alexander, Allyson; Soltesz, Ivan (2017) Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy. Neuroscientist 23:68-81
Szabo, Gergely G; Du, Xi; Oijala, Mikko et al. (2017) Extended Interneuronal Network of the Dentate Gyrus. Cell Rep 20:1262-1268
Maroso, Mattia; Szabo, Gergely G; Kim, Hannah K et al. (2016) Cannabinoid Control of Learning and Memory through HCN Channels. Neuron 89:1059-73
Alexander, A; Maroso, M; Soltesz, I (2016) Organization and control of epileptic circuits in temporal lobe epilepsy. Prog Brain Res 226:127-54
Bezaire, Marianne J; Raikov, Ivan; Burk, Kelly et al. (2016) Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit. Elife 5:
Krook-Magnuson, Esther; Soltesz, Ivan (2015) Beyond the hammer and the scalpel: selective circuit control for the epilepsies. Nat Neurosci 18:331-8
Lee, Sang-Hun; Ledri, Marco; Tóth, Blanka et al. (2015) Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release. J Neurosci 35:10039-57
Bui, Anh; Kim, Hannah K; Maroso, Mattia et al. (2015) Microcircuits in Epilepsy: Heterogeneity and Hub Cells in Network Synchronization. Cold Spring Harb Perspect Med 5:

Showing the most recent 10 out of 29 publications