Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS038231-01A1
Application #
2904748
Study Section
Special Emphasis Panel (ZRG1-IFCN-4 (01))
Program Officer
Kitt, Cheryl A
Project Start
1999-07-15
Project End
2002-06-30
Budget Start
1999-07-15
Budget End
2000-06-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Physiology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Martin, Thomas J; Coller, Michael; Co, Conchita et al. (2008) Micro-opioid receptor alkylation in the ventral pallidum and ventral tegmental area, but not in the nucleus accumbens, attenuates the effects of heroin on cocaine self-administration in rats. Neuropsychopharmacology 33:1171-8
Martin, Thomas J; Kahn, William R; Xiao, Royu et al. (2007) Differential regional effects of methadone maintenance compared to heroin dependence on mu-opioid receptor desensitization in rat brain. Synapse 61:176-84
Martin, Thomas J; Kim, Susy A; Buechler, Nancy L et al. (2007) Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology 106:312-22
Martin, Thomas J; McIntosh, Scot; Smith, James E (2006) Alkylation of opioid receptors by 5'-naltrindole-isothiocyanate injected into the nucleus accumbens of rats: receptor selectivity and anatomical diffusion. Synapse 60:384-91
Martin, Thomas J; Kahn, William; Cannon, David G et al. (2006) Self-administration of heroin, cocaine and their combination under a discrete trial schedule of reinforcement in rats. Drug Alcohol Depend 82:282-6
Martin, Thomas J; Buechler, Nancy L; Eisenach, James C (2006) Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats. Anesth Analg 103:690-5
Smith, James E; Co, Conchita; Coller, Michael D et al. (2006) Self-administered heroin and cocaine combinations in the rat: additive reinforcing effects-supra-additive effects on nucleus accumbens extracellular dopamine. Neuropsychopharmacology 31:139-50
Martin, Thomas J; Kahn, William R; Eisenach, James C (2005) Abdominal surgery decreases food-reinforced operant responding in rats: relevance of incisional pain. Anesthesiology 103:629-37
Martin, Thomas J; Buechler, Nancy L; Kahn, William et al. (2004) Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain. Anesthesiology 101:191-203
Martin, Thomas J; Kim, Susy A; Lyupina, Yulia et al. (2002) Differential involvement of mu-opioid receptors in the rostral versus caudal nucleus accumbens in the reinforcing effects of heroin in rats: evidence from focal injections of beta-funaltrexamine. Psychopharmacology (Berl) 161:152-9

Showing the most recent 10 out of 11 publications