This is a renewal application for the highly successful Brain Attack Surveillance in Corpus Christi (BASIC) Project. BASIC is the only ongoing stroke surveillance project focusing on Mexican Americans. Mexican Americans are the largest segment of the Hispanic American population, the United States'largest minority group. Since the inception of this project in January 2000, we have assembled a cohort of over 4,992 cerebrovascular disease patients for whom we are able to follow for recurrent cerebrovascular events as well as mortality. This gives us tremendous power to detect associations with biological and social risk factors for stroke, important to Mexican Americans as well as the broader United States population. We have demonstrated increased stroke incidence and recurrence in Mexican Americans. Stroke severity and ischemic stroke subtypes are similar between Mexican Americans and non-Hispanic whites. Mortality following stroke appears to be less in Mexican Americans. In the next five years we are positioned to delineate trends in stroke rates, and to explore the potential reasons for the increased stroke burden in Mexican Americans, as well as their improved survival. This information will be critically important to all populations to reduce the devastation of stroke. We will continue to make important observations useful for planning delivery of stroke care in communities. For the first time we will investigate functional and cognitive outcome following stroke in Mexican Americans and non-Hispanic whites. We will now also study the role of health care quality and medication compliance on stroke outcomes. We will collect blood on all stroke patients useful for genetic studies by our group and others, and we have initiated stroke surveillance in a similar community within Mexico that will serve as a great basis for comparison to the Corpus Christi population. BASIC has been a very prolific study with more than 27 original peer-reviewed publications in the last four years alone. Indeed, this study is just beginning to provide the rich epidemiologic and clinical data that are necessary to control the epidemic of cerebrovascular disease in Mexican Americans. We know that the next five years will allow us to make contributions that will be directly useful for interventions to reduce health disparities, prevent stroke and improve stroke outcomes in all populations.

Public Health Relevance

This is a competitive renewal for the Brain Attack Surveillance in Corpus Christi (BASIC) project. This highly successful community-based stroke epidemiology project seeks to understand the health disparity for stroke among Mexican Americans and non Hispanic whites in Corpus Christi, Texas. This accomplished through observational epidemiology and interviews of patients. No intervention is contained in the study.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS038916-15
Application #
8402841
Study Section
Neurological, Aging and Musculoskeletal Epidemiology (NAME)
Program Officer
Waddy, Salina P
Project Start
1999-09-01
Project End
2014-07-31
Budget Start
2013-02-01
Budget End
2014-07-31
Support Year
15
Fiscal Year
2013
Total Cost
$599,064
Indirect Cost
$227,745
Name
University of Michigan Ann Arbor
Department
Neurology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Brown, Devin L; Mowla, Ashkan; McDermott, Mollie et al. (2015) Ischemic stroke subtype and presence of sleep-disordered breathing: the BASIC sleep apnea study. J Stroke Cerebrovasc Dis 24:388-93
Burke, James F; Vijan, Sandeep; Chekan, Lynette A et al. (2014) Targeting high-risk employees may reduce cardiovascular racial disparities. Am J Manag Care 20:725-33
Brown, Devin L; McDermott, Mollie; Mowla, Ashkan et al. (2014) Brainstem infarction and sleep-disordered breathing in the BASIC sleep apnea study. Sleep Med 15:887-91
Skolarus, Lesli E; Sanchez, Brisa N; Levine, Deborah A et al. (2014) Association of body mass index and mortality after acute ischemic stroke. Circ Cardiovasc Qual Outcomes 7:64-9
De Lott, Lindsey B; Lisabeth, Lynda D; Sanchez, Brisa N et al. (2014) Prevalence of pre-stroke sleep apnea risk and short or long sleep duration in a bi-ethnic stroke population. Sleep Med 15:1582-5
Zahuranec, Darin B; Lisabeth, Lynda D; Sánchez, Brisa N et al. (2014) Intracerebral hemorrhage mortality is not changing despite declining incidence. Neurology 82:2180-6
Kerber, Kevin A; Zahuranec, Darin B; Brown, Devin L et al. (2014) Stroke risk after nonstroke emergency department dizziness presentations: a population-based cohort study. Ann Neurol 75:899-907
Kelly, Adam G; Zahuranec, Darin B; Holloway, Robert G et al. (2014) Variation in do-not-resuscitate orders for patients with ischemic stroke: implications for national hospital comparisons. Stroke 45:822-7
Brown, Devin L; Chervin, Ronald D; Hegeman 3rd, Garnett et al. (2014) Is technologist review of raw data necessary after home studies for sleep apnea? J Clin Sleep Med 10:371-5
Lisabeth, Lynda D; Sánchez, Brisa N; Baek, Jonggyu et al. (2014) Neurological, functional, and cognitive stroke outcomes in Mexican Americans. Stroke 45:1096-101

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