Pain-related disorders cause an incalculable toll in human suffering and present a significant economic problem. The development of new treatments for these disorders is being hindered by a lack of information about the basic brain mechanisms that support sensory aspects of pain experience. Functional imaging studies using functional magnetic resonance imaging (fMRI) provide powerful tools for addressing such issues in human subjects. Using such techniques, a highly distributed network of brain regions that may contribute to sensory discriminative pain processes has been identified. However, the involvement of specific components in supporting conscious awareness of discrete dimensions of pain, such as intensity and location, remains poorly understood. These perceived sensory aspects of pain can be dramatically modulated by cognitive interpretation and expectations about the nature of the stimulus. Yet, the brain mechanisms underlying this modulation remain unknown. A series of combined psychophysical and functional imaging studies will systematically test the hypotheses that 1) activation of the frontal cortex is necessary for subjective awareness of pain, 2) distinct parieto-frontal mechanisms are engaged in processes supporting conscious awareness of the location and intensity of painful stimuli, and 3) that activation within these areas can be modulated by internally-maintained contextual information. These studies will significantly enhance our knowledge of basic brain mechanisms underlying the pain experience, while simultaneously providing new directions for behavioral strategies of pain management.

Public Health Relevance

Pain afflicts more Americans than heart disease and stroke, diabetes, and cancer combined. Pain exacts an incalculable toll in human suffering and is a tremendous economic problem. The proposed research will focus on understanding the basic mechanisms that support the most clinically important features of pain - intensity and location - in order to provide a solid knowledge base for the development of improved treatments for pain.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Project (R01)
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Somatosensory and Chemosensory Systems Study Section (SCS)
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Babcock, Debra J
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Wake Forest University Health Sciences
Anatomy/Cell Biology
Schools of Medicine
United States
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Nahman-Averbuch, Hadas; Martucci, Katherine T; Granovsky, Yelena et al. (2014) Distinct brain mechanisms support spatial vs temporal filtering of nociceptive information. Pain 155:2491-501
Lobanov, Oleg V; Zeidan, Fadel; McHaffie, John G et al. (2014) From cue to meaning: brain mechanisms supporting the construction of expectations of pain. Pain 155:129-36
Emerson, Nichole M; Zeidan, Fadel; Lobanov, Oleg V et al. (2014) Pain sensitivity is inversely related to regional grey matter density in the brain. Pain 155:566-73
Zeidan, Fadel; Coghill, Robert C (2013) Functional connections between self-referential thought and chronic pain: a dysfunctional relationship. Pain 154:3-4
Lobanov, Oleg V; Quevedo, Alexandre S; Hadsel, Morten S et al. (2013) Frontoparietal mechanisms supporting attention to location and intensity of painful stimuli. Pain 154:1758-68
Zeidan, F; Grant, J A; Brown, C A et al. (2012) Mindfulness meditation-related pain relief: evidence for unique brain mechanisms in the regulation of pain. Neurosci Lett 520:165-73
Laurienti, Paul J; Joyce, Karen E; Telesford, Qawi K et al. (2011) Universal fractal scaling of self-organized networks. Physica A 390:3608-3613
Starr, Christopher J; Sawaki, Lumy; Wittenberg, George F et al. (2011) The contribution of the putamen to sensory aspects of pain: insights from structural connectivity and brain lesions. Brain 134:1987-2004
Zeidan, Fadel; Martucci, Katherine T; Kraft, Robert A et al. (2011) Brain mechanisms supporting the modulation of pain by mindfulness meditation. J Neurosci 31:5540-8
Martucci, Katherine T; Coghill, Robert C (2011) Regional anesthesia: functional implications beyond the anesthetized nerve. Anesthesiology 114:21-3

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