GABAergic neurons are a prominent class of neurons whose dysfunction can results in various disease states. The developmental mechanisms that result in terminal differentiation of GABAergic neurons and the functional properties of many GABAergic neurons are incompletely understood. We propose here to use the experimental advantages of the nematode C.elegans to decipher the gene regulatory events - both on the level of cis-regulatory elements and trans-acting factors - that induce the expression of terminal identity markers of a single GABAergic interneuron (Aim #1) and we propose to study a potential role of this GABAergic interneuron in controlling metabolic states and life span of C. elegans (Aim #2).

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS039996-13
Application #
8507279
Study Section
Special Emphasis Panel (ZRG1-MDCN-N (02))
Program Officer
Morris, Jill A
Project Start
2000-04-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
13
Fiscal Year
2013
Total Cost
$330,273
Indirect Cost
$123,401
Name
Columbia University (N.Y.)
Department
Biochemistry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Gendrel, Marie; Atlas, Emily G; Hobert, Oliver (2016) A cellular and regulatory map of the GABAergic nervous system of C. elegans. Elife 5:
Gordon, Patricia M; Hobert, Oliver (2015) A competition mechanism for a homeotic neuron identity transformation in C. elegans. Dev Cell 34:206-19
Kratsios, Paschalis; Pinan-Lucarré, Bérangère; Kerk, Sze Yen et al. (2015) Transcriptional coordination of synaptogenesis and neurotransmitter signaling. Curr Biol 25:1282-95
Murgan, Sabrina; Kari, Willi; Rothbächer, Ute et al. (2015) Atypical Transcriptional Activation by TCF via a Zic Transcription Factor in C. elegans Neuronal Precursors. Dev Cell 33:737-45
Alqadah, Amel; Hsieh, Yi-Wen; Vidal, Berta et al. (2015) Postmitotic diversification of olfactory neuron types is mediated by differential activities of the HMG-box transcription factor SOX-2. EMBO J 34:2574-89
Howell, Kelly; White, John G; Hobert, Oliver (2015) Spatiotemporal control of a novel synaptic organizer molecule. Nature 523:83-7
Stefanakis, Nikolaos; Carrera, Ines; Hobert, Oliver (2015) Regulatory Logic of Pan-Neuronal Gene Expression in C. elegans. Neuron 87:733-50
Vidal, Berta; Santella, Anthony; Serrano-Saiz, Esther et al. (2015) C. elegans SoxB genes are dispensable for embryonic neurogenesis but required for terminal differentiation of specific neuron types. Development 142:2464-77
Hobert, Oliver (2014) Development of left/right asymmetry in the Caenorhabditis elegans nervous system: from zygote to postmitotic neuron. Genesis 52:528-43
Glenwinkel, Lori; Wu, Di; Minevich, Gregory et al. (2014) TargetOrtho: a phylogenetic footprinting tool to identify transcription factor targets. Genetics 197:61-76

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